INT137032

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.51
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Il6, Tgfb1) extracellular space (Il6, Tgfb1) extracellular region (Il6, Tgfb1)
enzyme binding (Tgfb1) embryo development (Tgfb1) cytoplasm (Tgfb1)
Anatomy Link Frequency
PSCs 4
Il6 (Rattus norvegicus)
Tgfb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 6 81.44 Quite High
COX-2 inhibitor 2 68.00 Quite High
Chronic pancreatitis 4 51.24 Quite High
Inflammatory response 2 45.96 Quite Low
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 6 100.00 Very High Very High Very High
Pancreatitis 4 51.24 Quite High
INFLAMMATION 2 45.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, IL-1beta and IL-6 promote PSC activation by enhancing COX-2 expression indirectly through Smad2/3-dependent pathway by increasing TGF-beta1 secretion from PSCs.
IL-6 Positive_regulation (increasing) of Localization (secretion) of TGF-beta1 in PSCs associated with primary sclerosing cholangitis
1) Confidence 0.04 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.23 Pain Relevance 0.10
IL-6 as well as IL-1beta enhanced TGF-beta1 secretion from PSCs.
IL-6 Positive_regulation (enhanced) of Localization (secretion) of TGF-beta1 in PSCs
2) Confidence 0.04 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.28 Pain Relevance 0.16

General Comments

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