INT137043

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 16
Total Number 21
Disease Relevance 6.98
Pain Relevance 12.12

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cell differentiation (NAV1) cytoplasm (NAV1)
Anatomy Link Frequency
Caov-3 8
spermatozoa 6
plasma 1
NAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.7 83 100.00 Very High Very High Very High
Nav1.1 72 100.00 Very High Very High Very High
nav1.8 63 100.00 Very High Very High Very High
nav1.3 57 100.00 Very High Very High Very High
Nav1.2 43 100.00 Very High Very High Very High
sodium channel 443 99.44 Very High Very High Very High
tetrodotoxin 122 94.72 High High
imagery 6 88.60 High High
c fibre 7 88.56 High High
Nav1.9 28 83.48 Quite High
Disease Link Frequency Relevance Heat
Ovarian Cancer 56 99.36 Very High Very High Very High
Neuroblastoma 6 98.64 Very High Very High Very High
Reprotox - General 1 108 98.32 Very High Very High Very High
Cancer 12 96.88 Very High Very High Very High
Sperm Disorder 105 90.88 High High
Targeted Disruption 2 88.88 High High
Adhesions 8 86.24 High High
Pain 7 80.80 Quite High
Breast Cancer 4 75.00 Quite High
Nociception 7 68.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Spec (analyzed) Transcription (expression) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
1) Confidence 0.72 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.54 Pain Relevance 0.63
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Spec (analyzed) Transcription (levels) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
2) Confidence 0.69 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.55 Pain Relevance 0.64
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Spec (analyzed) Transcription (levels) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
3) Confidence 0.69 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.54 Pain Relevance 0.64
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Spec (analyzed) Transcription (levels) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
4) Confidence 0.69 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.55 Pain Relevance 0.64
Immunofluorescence studies demonstrate that, with the exception of Nav1.1 and Nav1.3, all VGSC proteins could be detected in mature sperm.
Neg (exception) Transcription (exception) of Nav1 in sperm associated with nav1.3 and nav1.1
5) Confidence 0.67 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.39
Of particular interest was the observation that Nav1.8 mRNA and protein are expressed in mature spermatozoa.
Transcription (expressed) of Nav1 in spermatozoa associated with nav1.8
6) Confidence 0.67 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0.15 Pain Relevance 0.91
Immunofluorescence studies demonstrate that, with the exception of Nav1.1 and Nav1.3, all VGSC proteins could be detected in mature sperm.
Neg (exception) Transcription (exception) of Nav1 in sperm associated with nav1.3 and nav1.1
7) Confidence 0.67 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.39
Furthermore, the total Nav1.5 mRNA and Navbeta1 mRNA were detected in 16 different tissue types of developing Wistar rats by reverse polymerase chain reaction (RT-PCR), and their expression patterns varied among different tissue types with age development.
Transcription (detected) of Nav1
8) Confidence 0.60 Published 2009 Journal Neurosci. Res. Section Abstract Doc Link 19376164 Disease Relevance 0 Pain Relevance 0.06
Moreover, the distribution of each Nav channel was very homogeneous within and throughout samples, with only minor changes in staining intensity.
Transcription (distribution) of Nav
9) Confidence 0.59 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.46
In the case of Nav1.7, both the wild type and the splice variant were detected in some sperm samples while only the splice variant was present in other sperm cDNAs (see Fig. 1) The mRNAs of the Nav ?
Transcription (mRNAs) of Nav in sperm associated with nav1.7
10) Confidence 0.59 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.83
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Transcription (expression) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
11) Confidence 0.53 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.67 Pain Relevance 0.65
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Transcription (expression) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
12) Confidence 0.53 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.68 Pain Relevance 0.65
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Transcription (expression) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
13) Confidence 0.53 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.67 Pain Relevance 0.65
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Transcription (expression) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
14) Confidence 0.53 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.67 Pain Relevance 0.65
The mRNAs that encode the different Nav alpha subunits (Nav1.1-1.9) were all expressed in capacitated human spermatozoa.
Transcription (expressed) of Nav1 in spermatozoa associated with nav1.1
15) Confidence 0.52 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2724540 Disease Relevance 0.23 Pain Relevance 0.41
The mRNAs that encode the different Nav alpha subunits (Nav1.1-1.9) were all expressed in capacitated human spermatozoa.
Transcription (expressed) of Nav in spermatozoa associated with nav1.1
16) Confidence 0.52 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2724540 Disease Relevance 0.24 Pain Relevance 0.41
2 increased mRNA and protein levels of Nav1.1 ?
Transcription (levels) of Nav1 associated with nav1.1
17) Confidence 0.49 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.62
2 resulting in elevated protein and mRNA levels of Nav1.1 ?
Transcription (levels) of Nav1 associated with nav1.1
18) Confidence 0.49 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.27 Pain Relevance 0.66
protein and Nav1.7 mRNA expression were also markedly up-regulated in human PCa in vivo [14].
Transcription (expression) of Nav1 associated with nav1.7 and reprotox - general 1
19) Confidence 0.39 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.82 Pain Relevance 0.78
It was concluded that EGF increased Nav1.7 mRNA expression, leading to de novo VGSC protein synthesis, directed mainly to plasma membrane.


Transcription (expression) of Nav1 in plasma associated with sodium channel and nav1.7
20) Confidence 0.39 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.16 Pain Relevance 0.83

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