INT137049

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 9.24
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Glrb) endoplasmic reticulum (Glrb) plasma membrane (Glrb)
Anatomy Link Frequency
bowel 3
macrophages 1
lymphocyte 1
Glrb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 118 100.00 Very High Very High Very High
Arthritis 110 100.00 Very High Very High Very High
spinal inflammation 70 100.00 Very High Very High Very High
rheumatoid arthritis 170 99.68 Very High Very High Very High
Crohn's disease 24 98.24 Very High Very High Very High
psoriasis 6 94.88 High High
corticosteroid 12 37.12 Quite Low
member 8 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 76 100.00 Very High Very High Very High
Low Back Pain 70 100.00 Very High Very High Very High
Arthritis 34 100.00 Very High Very High Very High
Inflammatory Bowel Disease 30 100.00 Very High Very High Very High
Sacroiliitis 2 100.00 Very High Very High Very High
Synovitis 64 99.96 Very High Very High Very High
Enterobacter Infection 2 99.90 Very High Very High Very High
Immunization 2 99.84 Very High Very High Very High
Rheumatoid Arthritis 170 99.68 Very High Very High Very High
Disease 334 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, neither synovial hypervascularity, which is clearly increased in SpA versus RA and contributes to diagnostic classification [1,7], nor lymphocyte-related characteristics (CD3, CD20, plasma cells, lymphoid aggregates) were associated with SJC, CRP, or ESR.
Positive_regulation (increased) of SpA in lymphocyte associated with rheumatoid arthritis
1) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.20 Pain Relevance 0.22
One cohort consisted of 82 patients, including 19 with ankylosing spondylitis (AS), 33 with PsA, 24 with undifferentiated SpA (USpA), 4 with SpA associated with inflammatory bowel disease, and 2 with reactive arthritis.
Positive_regulation (undifferentiated) of SpA in bowel associated with seronegative spondarthritis, spinal inflammation, inflammation and arthritis
2) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.45 Pain Relevance 0.54
Immunization of mice with proteoglycan aggrecan also can provoke SpA, thus providing the opportunity to study genetic and clinical details of the disease initiation.
Positive_regulation (provoke) of SpA associated with immunization and disease
3) Confidence 0.38 Published 2006 Journal Curr Rheumatol Rep Section Abstract Doc Link 16839505 Disease Relevance 0.69 Pain Relevance 0.19
We previously shown that these CD163+ macrophages, but not the overall number of CD68+ macrophages, are increased in SpA synovitis and play a specific role in the disease pathogenesis [2,26].
Positive_regulation (increased) of SpA in macrophages associated with synovitis and disease
4) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.20 Pain Relevance 0.20
Animal models confirmed the primary role of MHC in SpA susceptibility and supported the hypothesis that certain enterobacterial infections can trigger SpA.
Positive_regulation (trigger) of SpA associated with enterobacter infection
5) Confidence 0.35 Published 2006 Journal Curr Rheumatol Rep Section Abstract Doc Link 16839505 Disease Relevance 0.61 Pain Relevance 0.20
There was also a trend towards an increase of PMNs in SpA (P = 0.062).
Positive_regulation (increase) of SpA
6) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 0.82 Pain Relevance 0.25
Depending on its clinical features, SpA is classically subdivided into the following subsets: ankylosing spondylitis (AS), which is the prototypical form characterized by predominant axial skeletal involvement and advanced radiographic sacroiliitis, psoriatic arthritis (PsA), arthritis associated with inflammatory bowel disease (AIBD), reactive arthritis (ReA), and undifferentiated SpA (uSpA).
Positive_regulation (undifferentiated) of SpA in bowel associated with seronegative spondarthritis, spinal inflammation, sacroiliitis, inflammation and arthritis
7) Confidence 0.19 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 1.57 Pain Relevance 0.78
Depending on its clinical features, SpA is classically subdivided into the following subsets: ankylosing spondylitis (AS), which is the prototypical form characterized by predominant axial skeletal involvement and advanced radiographic sacroiliitis, psoriatic arthritis (PsA), arthritis associated with inflammatory bowel disease (AIBD), reactive arthritis (ReA), and undifferentiated SpA (uSpA).
Positive_regulation (undifferentiated) of SpA in bowel associated with seronegative spondarthritis, spinal inflammation, sacroiliitis, inflammation and arthritis
8) Confidence 0.19 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 1.70 Pain Relevance 0.84

General Comments

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