INT137052

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 4.72
Pain Relevance 6.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PYCARD) signal transduction (PYCARD) intracellular (PYCARD)
cytoplasm (PYCARD)
Anatomy Link Frequency
neural 3
neurons 1
Nodes 1
HeLa 1
brain 1
PYCARD (Homo sapiens)
Pain Link Frequency Relevance Heat
Transcranial magnetic stimulation 1773 100.00 Very High Very High Very High
long-term potentiation 6 98.68 Very High Very High Very High
fluoxetine 5 98.18 Very High Very High Very High
imagery 85 98.16 Very High Very High Very High
depression 108 92.72 High High
antidepressant 19 91.84 High High
Inflammation 21 82.20 Quite High
nerve block 80 79.44 Quite High
Facet joint 60 78.56 Quite High
Central nervous system 2 77.88 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 33 99.90 Very High Very High Very High
Infection 23 98.36 Very High Very High Very High
Disease 83 98.32 Very High Very High Very High
Stress 96 96.76 Very High Very High Very High
Brain Disease 6 93.92 High High
Anxiety Disorder 92 93.20 High High
Depression 107 92.72 High High
Frailty 2 90.08 High High
Otitis Media 71 83.80 Quite High
Convulsion 27 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, by identifying distal regions activated during TMS, researchers can infer connectivity patterns in the healthy human brain and can examine how those patterns may be disrupted in patients with different brain disorders.
Positive_regulation (activated) of TMS in brain associated with brain disease and transcranial magnetic stimulation
1) Confidence 0.43 Published 2010 Journal Frontiers in Systems Neuroscience Section Abstract Doc Link PMC2950743 Disease Relevance 0.25 Pain Relevance 0.31
Nodes in this dysfunctional network accessible as targets for TMS by virtue of their proximity to the scalp may then permit TMS-induced alterations of components of the network not directly accessible to TMS via propagated effects.
Neg (not) Positive_regulation (accessible) of TMS in Nodes associated with transcranial magnetic stimulation
2) Confidence 0.43 Published 2010 Journal Frontiers in Systems Neuroscience Section Abstract Doc Link PMC2950743 Disease Relevance 0.21 Pain Relevance 0.38
Figure 5 shows the time-course of the change in visual discrimination performance following rTMS for the same subjects shown in Figure 4.
Positive_regulation (following) of rTMS
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860988 Disease Relevance 0 Pain Relevance 0.04
Thompson et al. [27] demonstrated a double dissociation for coherent motion perception following rTMS stimulation of V1 and V5/MT, suggesting competing percepts from different visual areas.
Positive_regulation (stimulation) of rTMS
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860988 Disease Relevance 0 Pain Relevance 0.03
Haggard and Whitford [2] showed that TMS stimulation over SMA prior to a voluntary movement removed the sensory suppression effect, which normally accompanies voluntary movements [22].
Positive_regulation (stimulation) of TMS
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952623 Disease Relevance 0 Pain Relevance 0
This combination of results in Experiment 1 appears more consistent with the possibility that TMS activates neurons in the TMS-targeted hemisphere that go on to exert beneficial influences on the opposite hemisphere, instead of disrupting the TMS-targeted hemisphere (which should have led to a contralateral impairment that we did not find) and thereby putatively ‘disinhibiting’ the other hemisphere.
Positive_regulation (disrupting) of TMS-targeted in neurons associated with transcranial magnetic stimulation
6) Confidence 0.41 Published 2010 Journal Neuropsychologia Section Body Doc Link PMC2956832 Disease Relevance 0 Pain Relevance 0.36
Therefore, this study provides indirect evidence (constituted by our offline TMS over MFG results) for the functional relevance of remote neural effects of TMS (the decrease of MFG activation found by Sack et al. [21] during TMS over PPC).
Positive_regulation (activation) of TMS in neural associated with transcranial magnetic stimulation
7) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.47
Therefore, this study provides indirect evidence (constituted by our offline TMS over MFG results) for the functional relevance of remote neural effects of TMS (the decrease of MFG activation found by Sack et al. [21] during TMS over PPC).
Positive_regulation (activation) of TMS in neural associated with transcranial magnetic stimulation
8) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.47
Stimulation in the TMS conditions was at an intensity of 120% of individual motor threshold.
Positive_regulation (Stimulation) of TMS associated with transcranial magnetic stimulation
9) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.34
Participants were given an ear plug for their right ear to protect hearing and to minimize distraction from the auditory stimulation of TMS pulses.
Positive_regulation (stimulation) of TMS in ear associated with transcranial magnetic stimulation
10) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.21
An important caveat, though, is that most of the trials to date have only compared rTMS to a sham control over a 2-week period, whereas evidence from trials allowing longer treatment periods, either in an open extension (eg, Loo et al 1999) or within the controlled phase (Rumi et al 2005), suggests further improvement occurs with increasing duration of rTMS.
Positive_regulation (increasing) of rTMS
11) Confidence 0.39 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671781 Disease Relevance 0.18 Pain Relevance 0.16
We did not use an offline TMS protocol at a lower frequency, as it would seem difficult to directly compare an online protocol at one frequency (e.g., bursts of 10 Hz TMS on each trial) to an offline protocol at a different frequency (e.g., prolonged 1 Hz TMS).
Positive_regulation (prolonged) of TMS associated with transcranial magnetic stimulation
12) Confidence 0.38 Published 2010 Journal Neuropsychologia Section Body Doc Link PMC2956832 Disease Relevance 0.07 Pain Relevance 0.43
Reversed TMS could potentially serve as sham TMS since Reversed causes less cortical stimulation compared to Standard TMS when the coil is placed in an optimal orientation for Standard TMS (see Motor Physiology above and [21]).
Positive_regulation (orientation) of TMS associated with transcranial magnetic stimulation
13) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0 Pain Relevance 0.76
In the present experiments, increasing TMS stimulation intensity by 10% produced changes that were reliably detected by the DI.
Positive_regulation (increasing) of TMS associated with transcranial magnetic stimulation
14) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858649 Disease Relevance 0.22 Pain Relevance 0.20
In the region centered at 205 nm, there is an Asc concentration dependent increase in the absorbance, indicating a second binding of Asc, with this binding in the physiological Asc concentration range.
Positive_regulation (increase) of Asc
15) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0
The decreased binding was associated with significantly increased Asc oxidation rates in the untransfected cell preparations compared with the transfected ones [4].
Positive_regulation (increased) of Asc
16) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0
To study the mechanisms of neural modulation of repetitive transcranial magnetic stimulation (rTMS) and fluoxetine, 21 PD depressed patients were randomized into only two active treatment groups for 4 wk: active rTMS over left dorsolateral prefrontal cortex (DLPFC) (5 Hz rTMS; 120% motor threshold) with placebo pill and sham rTMS with fluoxetine 20 mg/d.
Positive_regulation (active) of rTMS in neural associated with transcranial magnetic stimulation, disease and fluoxetine
17) Confidence 0.23 Published 2008 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 17708780 Disease Relevance 0.42 Pain Relevance 0.44
We identified 30 publications that described patients with epilepsy who underwent rTMS, and noted total number of relevant subjects, medication usage, incidence of adverse events, and rTMS parameters including stimulus frequency, number of stimuli, train duration, intertrain interval, coil type, and stimulation sites.
Positive_regulation (underwent) of rTMS associated with epilepsy
18) Confidence 0.21 Published 2007 Journal Epilepsy Behav Section Abstract Doc Link 17493877 Disease Relevance 0.94 Pain Relevance 0.07
Since SK&P was comparable to flotation rest in inducing ASC, it indicates that a very deep relaxation was experienced as a result of SK&P which could be the basis for the effects that are observed on wellness parameters.
Positive_regulation (inducing) of ASC
19) Confidence 0.21 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2231388 Disease Relevance 0.14 Pain Relevance 0
Note that in the 100 Asc (with no AR), and to a lesser extent in the 30 Asc (with no AR), series of lines, the superimposed spectra are distinguishable, with the Asc absorbance centered at 266 nm disappearing with time.
Positive_regulation (distinguishable) of Asc
20) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0

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