INT137056

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.92
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
liver 6
lungs 4
plasma 2
hepatocytes 2
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 14 86.40 High High
addiction 1 85.20 High High
opiate 2 84.76 Quite High
antagonist 1 78.84 Quite High
cytokine 21 78.56 Quite High
chemokine 25 50.00 Quite Low
Paracetamol 2 25.00 Low Low
anesthesia 5 10.68 Low Low
Inflammation 17 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 31 100.00 Very High Very High Very High
Injury 91 99.92 Very High Very High Very High
Infection 14 98.84 Very High Very High Very High
Hepatitis 4 98.36 Very High Very High Very High
Cirrhosis 6 97.80 Very High Very High Very High
Liver Disease 3 96.84 Very High Very High Very High
Congenital Anomalies 5 96.16 Very High Very High Very High
Hepatotoxicity 14 89.96 High High
Toxicity 10 88.60 High High
Cv Unclassified Under Development 14 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
gpt Mutations in the lungs of gpt transgenic mice with particle treatment
Regulation (lungs) of Gene_expression (transgenic mice) of gpt in lungs associated with targeted disruption
1) Confidence 0.39 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.41 Pain Relevance 0
Spi- MFs in the lungs of gpt transgenic mice with particle treatment
Regulation (lungs) of Gene_expression (transgenic mice) of gpt in lungs associated with targeted disruption
2) Confidence 0.39 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.15 Pain Relevance 0
Demonstration of hepatocellular injury by changes in plasma ALT levels
Regulation (changes) of Gene_expression (levels) of ALT in plasma associated with injury
3) Confidence 0.25 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.19 Pain Relevance 0.04
To improve the diagnostic value of the ALT assay and to understand the molecular basis for serum ALT changes in various pathophysiological conditions, we have cloned rat ALT isoenzyme ALT1 and ALT2 complementary DNAs (cDNAs), examined their tissue expressions at the messenger RNA and protein levels, and determined ALT1 and ALT 2 serum levels in response to liver damage in rodents.
Regulation (value) of Gene_expression (assay) of ALT in liver associated with hepatotoxicity
4) Confidence 0.22 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.82 Pain Relevance 0
To improve the diagnostic value of the ALT assay and to understand the molecular basis for serum ALT changes in various pathophysiological conditions, we have cloned rat ALT isoenzyme ALT1 and ALT2 complementary DNAs (cDNAs), examined their tissue expressions at the messenger RNA and protein levels, and determined ALT1 and ALT 2 serum levels in response to liver damage in rodents.
Regulation (basis) of Gene_expression (changes) of ALT in liver associated with hepatotoxicity
5) Confidence 0.19 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.86 Pain Relevance 0
After the 12-week treatment, levels of the hepatic enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) did not show any elevation, except in one subject, and the results strongly support that NTX did not induce abnormalities in liver function tests or elevate the liver enzymes.
Neg (except) Regulation (show) of Gene_expression (levels) of ALT in liver associated with congenital anomalies
6) Confidence 0.09 Published 2006 Journal Alcohol Section Abstract Doc Link 16839858 Disease Relevance 0.50 Pain Relevance 0.25
Effect of quercetin on levels of ALT, AST, ADH, ?
Regulation (Effect) of Gene_expression (levels) of ALT
7) Confidence 0.03 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900062 Disease Relevance 0.26 Pain Relevance 0.04
Changes in ALT and AST levels in the 48 hour period following SIRT are shown in Table 3.
Regulation (Changes) of Gene_expression (levels) of ALT
8) Confidence 0.03 Published 2005 Journal BMC Nucl Med Section Body Doc Link PMC1360059 Disease Relevance 0.48 Pain Relevance 0
The PEGylated virus transduced hepatocytes in a similar manner to AdlacZ without affecting ALT, but still altered CYP expression and function (Figures 7 and 8).
Regulation (altered) of Gene_expression (expression) of ALT in hepatocytes
9) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.24 Pain Relevance 0

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