INT13706

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1981
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.83
Pain Relevance 5.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
pancreatic islets 1
retina 1
endothelial cells 1
neurons 1
duodenum 1
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 2 100.00 Very High Very High Very High
sodium channel 2 100.00 Very High Very High Very High
Dopamine 21 99.98 Very High Very High Very High
Neurotransmitter 3 99.98 Very High Very High Very High
Morphine 17 99.84 Very High Very High Very High
Clonidine 8 99.68 Very High Very High Very High
agonist 8 99.60 Very High Very High Very High
Glutamate 3 99.36 Very High Very High Very High
Kappa opioid receptor 2 99.18 Very High Very High Very High
narcan 4 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 1 97.16 Very High Very High Very High
Hyperalgesia 3 94.56 High High
Increased Venous Pressure Under Development 3 86.68 High High
Inflammatory Pain 1 75.00 Quite High
Bordatella Infection 1 63.80 Quite High
Cancer 1 61.48 Quite High
Vibrio Infection 1 59.12 Quite High
Glioma 1 51.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of nitric oxide donors on endogenous dopamine release from rat striatal slices.
Localization (release) of cyclase associated with dopamine
1) Confidence 0.59 Published 1997 Journal Fundam Clin Pharmacol Section Title Doc Link 9444520 Disease Relevance 0 Pain Relevance 0.89
Since ACh induces nitric oxide (NO) release from endothelial cells which is though to stimulate guanylate cyclase (GC) we investigated if NO-cyclic GMP pathway was involved in the analgesia by those agents.
Localization (release) of guanylate cyclase in endothelial cells associated with analgesia
2) Confidence 0.50 Published 1991 Journal Agents Actions Suppl. Section Abstract Doc Link 1676874 Disease Relevance 0.08 Pain Relevance 0.79
Inhibitors of NO synthase (NG-nitro- and NG-amino-L-arginine) and guanylate cyclase (LY83583) elevated release.
Localization (release) of guanylate cyclase
3) Confidence 0.28 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7637891 Disease Relevance 0 Pain Relevance 0.54
Prostaglandin E2 is a metabotropic transmitter, activating adenylate cyclase, either directly or through the release of a stimulatory protein factor.
Localization (release) of cyclase
4) Confidence 0.15 Published 1981 Journal Agents Actions Section Abstract Doc Link 6280466 Disease Relevance 0.36 Pain Relevance 0.34
Inhibitory effect of clonidine upon adenylate cyclase activity, cyclic AMP production, and insulin release in rat pancreatic islets.
Localization (release) of cyclase in pancreatic islets associated with clonidine
5) Confidence 0.08 Published 1984 Journal Biosci. Rep. Section Title Doc Link 6087950 Disease Relevance 0.06 Pain Relevance 0.60
Adaptive changes in the number of Gs- and Gi-proteins underlie adenylyl cyclase sensitization in morphine-treated rat striatal neurons.
Localization (sensitization) of cyclase in neurons associated with morphine
6) Confidence 0.06 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8386668 Disease Relevance 0.06 Pain Relevance 0.56
These results demonstrate a role for Galphao in adenylyl cyclase supersensitization after mu-agonist exposure and show that this action is modulated by endogenous RGS proteins.
Localization (supersensitization) of cyclase associated with agonist
7) Confidence 0.06 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15014136 Disease Relevance 0.12 Pain Relevance 0.53
Mu-, delta- and kappa-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fentanyl isothiocyanate.
Localization (release) of cyclase in brain associated with neurotransmitter, narcan and kappa opioid receptor
8) Confidence 0.06 Published 1988 Journal Eur. J. Pharmacol. Section Title Doc Link 2906610 Disease Relevance 0 Pain Relevance 0.96
The localization of COX and soluble guanylyl cyclase in rat retina was examined using immunohistochemistry.
Spec (examined) Localization (localization) of cyclase in retina
9) Confidence 0.05 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19625688 Disease Relevance 0.16 Pain Relevance 0.12
Folskolin (250 micrograms/kg, iv), the stimulator of adenylate cyclase, also increased HCO3- secretion in the duodenum but not in the stomach.
Neg (not) Localization (secretion) of cyclase in duodenum
10) Confidence 0.04 Published 1997 Journal J. Physiol. Paris Section Abstract Doc Link 9403800 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox