INT137077

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
stem cells 1
Rmp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 9 99.76 Very High Very High Very High
palliative 1 98.28 Very High Very High Very High
hyperexcitability 12 85.08 High High
Hyperalgesia 22 66.36 Quite High
Lasting pain 2 65.68 Quite High
Spinal cord 2 64.68 Quite High
narcan 5 63.92 Quite High
Dorsal horn 11 63.88 Quite High
Morphine 41 62.16 Quite High
withdrawal 21 61.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 5 95.48 Very High Very High Very High
Injury 6 69.16 Quite High
Nervous System Injury 26 67.36 Quite High
Hyperalgesia 42 66.36 Quite High
Pain 10 65.68 Quite High
Nociception 2 62.80 Quite High
Hypersensitivity 4 51.20 Quite High
Anxiety Disorder 1 50.08 Quite High
Neuropathic Pain 42 50.00 Quite Low
Drug Dependence 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that CCI treatment significantly increased excitability of the neurons from the WT mice, the RMP was depolarized, the AP current threshold lowered, the repetitive discharge following depolarizing current increased.
Gene_expression (depolarized) of RMP in neurons associated with action potential
1) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.55 Pain Relevance 0.76
It is conceivable that drug resistance gene transfer into bone marrow stem cells may be able to reduce or abolish chemotherapy-induced myelosuppression and facilitate the use of high dose chemotherapy.
Gene_expression (transfer) of resistance in stem cells
2) Confidence 0.00 Published 2006 Journal Curr Drug Targets Section Abstract Doc Link 16842217 Disease Relevance 0.26 Pain Relevance 0.10

General Comments

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