INT137080

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.34
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Agtr2) transcription factor binding (Agtr2) signal transducer activity (Agtr2)
Anatomy Link Frequency
neuronal 2
Agtr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 100.00 Very High Very High Very High
Locus ceruleus 5 97.32 Very High Very High Very High
Neuronal excitability 2 97.20 Very High Very High Very High
tolerance 5 95.60 Very High Very High Very High
antagonist 6 92.16 High High
Potency 1 69.16 Quite High
Clonidine 1 67.80 Quite High
agonist 5 67.40 Quite High
bradykinin 6 9.56 Low Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 10 99.12 Very High Very High Very High
Increased Venous Pressure Under Development 8 92.32 High High
Colon Cancer 35 91.92 High High
Chronic Renal Failure 1 83.88 Quite High
Heart Rate Under Development 2 82.84 Quite High
Hypertension 1 81.80 Quite High
Cancer 60 75.04 Quite High
Apoptosis 21 74.28 Quite High
Myocardial Infarction 47 71.56 Quite High
Metastasis 13 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggested that up-regulation of A2R and altered non-NMDA glutamate receptor function induced by chronic hypobaric hypoxia may underlie, in part, the decreased LC neuronal excitability and acute hypoxia tolerance.
Positive_regulation (up-regulation) of Positive_regulation (induced) of A2R in neuronal associated with neuronal excitability, hypoxia, locus ceruleus, glutamate receptor and tolerance
1) Confidence 0.26 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842765 Disease Relevance 0.54 Pain Relevance 0.74
PLA2, a key signalling molecule induced by AT2R activation [18,19], showed a similar result with increased staining corresponding to increasing concentrations of CGP42112A treatment (Figure 3B).
Positive_regulation (induced) of Positive_regulation (activation) of AT2R
2) Confidence 0.19 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.86 Pain Relevance 0
The blockade of AT1 receptor results in enhanced stimulation of the AT2 receptor.
Positive_regulation (enhanced) of Positive_regulation (stimulation) of AT2 receptor
3) Confidence 0.07 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.94 Pain Relevance 0

General Comments

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