INT137123

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.70
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Anatomy Link Frequency
optic nerves 2
macrophages 1
microglia 1
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 19 71.36 Quite High
cytokine 13 70.32 Quite High
Neuritis 10 50.00 Quite Low
antagonist 18 47.76 Quite Low
COX2 2 10.00 Low Low
Spinal cord 31 7.80 Low Low
Multiple sclerosis 9 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 21 71.36 Quite High
Demyelinating Disease 8 67.36 Quite High
Optic Neuritis 8 65.84 Quite High
Multiple Sclerosis 40 55.96 Quite High
Autoimmune Disease 9 50.00 Quite Low
Disease 14 45.76 Quite Low
Immunization 4 31.60 Quite Low
Death 2 5.00 Very Low Very Low Very Low
Experimental Autoimmune Neuritis 2 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(D) MBP-specific antibody production remains unchanged after BZ194 treatment.
Neg (unchanged) Regulation (unchanged) of Gene_expression (production) of MBP-specific
1) Confidence 0.25 Published 2010 Journal Brain Section Body Doc Link PMC2892943 Disease Relevance 0.18 Pain Relevance 0.10
RESULTS: In the affected pathologic nerve, iNOS-positive macrophages/microglia, iNOS-positive astrocytes, COX-2, and nitrotyrosine were observed. iNOS and COX-2 were occasionally observed in the unaffected nerve.
Regulation (unaffected) of in microglia Gene_expression (expression) of MBP in optic nerves
2) Confidence 0.23 Published 2006 Journal J Neuroophthalmol Section Body Doc Link 16845306 Disease Relevance 0.26 Pain Relevance 0
RESULTS: In the affected pathologic nerve, iNOS-positive macrophages/microglia, iNOS-positive astrocytes, COX-2, and nitrotyrosine were observed. iNOS and COX-2 were occasionally observed in the unaffected nerve.
Regulation (unaffected) of in macrophages Gene_expression (expression) of MBP in optic nerves
3) Confidence 0.08 Published 2006 Journal J Neuroophthalmol Section Body Doc Link 16845306 Disease Relevance 0.26 Pain Relevance 0

General Comments

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