INT137144

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Context Info
Confidence 0.20
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.13
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ITIH4, OPRM1) extracellular region (ITIH4) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) signal transducer activity (OPRM1) cytoplasm (ITIH4)
Anatomy Link Frequency
HL-60 2
ITIH4 (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 18 100.00 Very High Very High Very High
Opioid 4 98.56 Very High Very High Very High
narcan 2 85.40 High High
Morphine 2 82.48 Quite High
Inflammation 2 79.72 Quite High
cytokine 2 79.20 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 99.94 Very High Very High Very High
Opiate Addiction 2 98.56 Very High Very High Very High
Infection 2 94.72 High High
INFLAMMATION 2 79.72 Quite High
Leukemia 2 71.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells.
gp120 Regulation (regulation) of mu opioid receptor in HL-60 associated with acquired immune deficiency syndrome or hiv infection and mu opioid receptor
1) Confidence 0.20 Published 2006 Journal Int. Immunopharmacol. Section Title Doc Link 16846840 Disease Relevance 0.70 Pain Relevance 0.64
Our data suggest that one of the mechanisms by which HIV-1 gp120 up-regulates the MOR in TPA-differentiated HL-60 cells is through autocrine/paracrine actions of TNF-alpha via the TNFR-II receptor.
gp120 Regulation (regulates) of MOR in HL-60 associated with acquired immune deficiency syndrome or hiv infection and mu opioid receptor
2) Confidence 0.17 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16846840 Disease Relevance 0.43 Pain Relevance 0.52

General Comments

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