INT13716

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Context Info
Confidence 0.68
First Reported 1987
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 33
Total Number 35
Disease Relevance 19.11
Pain Relevance 16.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TH) cytosol (TH) mitochondrion (TH)
small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)
Anatomy Link Frequency
neurons 4
Th17 cells 3
sciatic nerve 2
brain 1
joint 1
TH (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 21 99.92 Very High Very High Very High
Arthritis 405 99.84 Very High Very High Very High
Morphine 30 99.84 Very High Very High Very High
Glutamate 5 99.80 Very High Very High Very High
Dopamine 509 99.76 Very High Very High Very High
Sciatic nerve 6 99.70 Very High Very High Very High
Locus ceruleus 10 99.68 Very High Very High Very High
Ventral tegmentum 8 99.68 Very High Very High Very High
Inflammation 110 99.36 Very High Very High Very High
Eae 8 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 924 99.92 Very High Very High Very High
Rheumatoid Arthritis 386 99.84 Very High Very High Very High
Sleep Disorders 242 99.50 Very High Very High Very High
INFLAMMATION 125 99.36 Very High Very High Very High
Opiate Addiction 4 99.28 Very High Very High Very High
Injury 9 99.26 Very High Very High Very High
Thyroid Disease 77 98.70 Very High Very High Very High
Neuroblastoma 9 98.68 Very High Very High Very High
Generalized Anxiety Disorder 2 98.56 Very High Very High Very High
Interstitial Cystitis 7 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased tyrosine hydroxylase immunoreactivity in the locus coeruleus of cats with interstitial cystitis.
Positive_regulation (Increased) of tyrosine hydroxylase immunoreactivity in locus coeruleus associated with locus ceruleus and interstitial cystitis
1) Confidence 0.68 Published 1998 Journal J. Urol. Section Title Doc Link 9474229 Disease Relevance 0.61 Pain Relevance 0.86
TH and alpha-synuclein mRNA levels were, in contrast, elevated in the VTA PN in heroin users with no change of the D2 receptor.
Positive_regulation (elevated) of TH associated with ventral tegmentum and opiate addiction
2) Confidence 0.57 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.42 Pain Relevance 0.78
The induction of Ts activity displayed a bimodal response at concentrations between 10(-12) to 10(-13) M and 10(-9) to 10(-10) M, while the induction of Th activity was consistently observed at 10(-11) M.
Positive_regulation (induction) of Th
3) Confidence 0.49 Published 1991 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 1676942 Disease Relevance 0 Pain Relevance 0.47
At 2 weeks after chronic constriction injury (CCI) of the sciatic nerve, a remarkable increase in tyrosine-hydroxylase (TH) and dopamine beta-hydroxylase (DbetaH) immunoreactive (IR) axonal terminals was observed in the ipsilateral L4-L6 dorsal horn.
Positive_regulation (increase) of tyrosine-hydroxylase in sciatic nerve associated with dopamine, eae, injury, dorsal horn and sciatic nerve
4) Confidence 0.48 Published 2003 Journal Brain Res. Section Abstract Doc Link 12706252 Disease Relevance 0.95 Pain Relevance 1.43
At 2 weeks after chronic constriction injury (CCI) of the sciatic nerve, a remarkable increase in tyrosine-hydroxylase (TH) and dopamine beta-hydroxylase (DbetaH) immunoreactive (IR) axonal terminals was observed in the ipsilateral L4-L6 dorsal horn.
Positive_regulation (increase) of TH in sciatic nerve associated with dopamine, eae, injury, dorsal horn and sciatic nerve
5) Confidence 0.48 Published 2003 Journal Brain Res. Section Abstract Doc Link 12706252 Disease Relevance 0.95 Pain Relevance 1.43
Most of the neuropeptide-containing neurons and nerve fibres were also reactive for tyrosine hydroxylase.
Positive_regulation (reactive) of tyrosine hydroxylase in neurons associated with neuropeptide
6) Confidence 0.46 Published 1990 Journal Histochem. J. Section Abstract Doc Link 1970339 Disease Relevance 0.18 Pain Relevance 0.55
A1 hybrid neurons also express messages for choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and glutamic acid decarboxylase (GAD), indicating that they could differentiate into various subsets of neuronal types.
Positive_regulation (messages) of tyrosine hydroxylase in neurons associated with generalized anxiety disorder
7) Confidence 0.46 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.47 Pain Relevance 0.17
A1 hybrid neurons also express messages for choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and glutamic acid decarboxylase (GAD), indicating that they could differentiate into various subsets of neuronal types.
Positive_regulation (messages) of TH in neurons associated with generalized anxiety disorder
8) Confidence 0.46 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.47 Pain Relevance 0.17
Th activity was consistently enhanced at 10(-13) M Tyr-Gly-Gly and 10(-14) M Tyr-Gly.
Positive_regulation (enhanced) of Th
9) Confidence 0.43 Published 1991 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 1676942 Disease Relevance 0 Pain Relevance 0.51
It was also positive for tyrosine hydroxylase, suggesting a post-ganglionic sympathetic origin.
Positive_regulation (positive) of tyrosine hydroxylase in sympathetic
10) Confidence 0.30 Published 2005 Journal J Bone Joint Surg Am Section Body Doc Link 15995126 Disease Relevance 0.07 Pain Relevance 0
In the immersion-fixed brains, optimal immunoreaction for tyrosine hydroxylase and glutamate decarboxylase was limited to a depth of 1-2 mm from the surface of the brain slice.
Positive_regulation (immunoreaction) of tyrosine hydroxylase in brain associated with glutamate
11) Confidence 0.25 Published 1987 Journal J. Neurosci. Methods Section Abstract Doc Link 2437408 Disease Relevance 0 Pain Relevance 0.22
Inclusion of OFQ/N during chronic morphine exposure also blocked morphine-induced TH upregulation.
Positive_regulation (upregulation) of TH associated with morphine
12) Confidence 0.21 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399106 Disease Relevance 0.07 Pain Relevance 1.18
Morphine-induced TH upregulation was blocked upon inclusion of a MEK-1 (mitogen-activated protein kinase kinase-1) inhibitor (PD98059), confirming the role for ERKs in this adaptive response to morphine.
Positive_regulation (upregulation) of TH associated with morphine
13) Confidence 0.21 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399106 Disease Relevance 0.14 Pain Relevance 1.41
Chromaffin cells from all three species reacted for TH, DBH and PNMT in co-culture and were histo-fluorescent.
Positive_regulation (reacted) of TH in Chromaffin cells
14) Confidence 0.20 Published 1989 Journal Exp Brain Res Section Abstract Doc Link 2568944 Disease Relevance 0.34 Pain Relevance 0.45
Instead the effect was limited to enhancing the number of TH-positive neurons.
Positive_regulation (enhancing) of TH in neurons
15) Confidence 0.18 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0 Pain Relevance 0.04
One manifestation of the behavioral changes resulting from chronic use of morphine is the upregulation of tyrosine hydroxylase (TH, the rate-limiting enzyme in catecholamine biosynthesis), which contributes to the dramatic increases in catecholamine release in the target regions of the locus coeruleus (LC) and the ventral tegmental area (VTA).
Positive_regulation (upregulation) of TH in ventral associated with ventral tegmentum, locus ceruleus, catecholamine and morphine
16) Confidence 0.18 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399106 Disease Relevance 0.16 Pain Relevance 1.14
Most of the neuropeptide-containing neurons and nerve fibres were also reactive for tyrosine hydroxylase.
Positive_regulation (reactive) of tyrosine hydroxylase in nerve associated with neuropeptide
17) Confidence 0.16 Published 1990 Journal Histochem. J. Section Abstract Doc Link 1970339 Disease Relevance 0.18 Pain Relevance 0.55
If these augmented TH levels are not counterbalanced by the DA system, RLS would appear.
Positive_regulation (augmented) of TH associated with dopamine and restless legs syndrome
18) Confidence 0.07 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 1.04 Pain Relevance 0.13
Several drugs that alleviate the symptoms of RLS are inducers of CYP450 activity, as induced CYP450 activity leads to enhanced degradation activity, causing TH levels to diminish.
Positive_regulation (causing) of TH associated with restless legs syndrome
19) Confidence 0.06 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 1.12 Pain Relevance 0.42
Moreover, elevated TH is not the only factor that can cause RLS, but it is the inciting condition for the syndrome, not the syndrome on its own.
Positive_regulation (elevated) of TH associated with syndrome and restless legs syndrome
20) Confidence 0.06 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 0.73 Pain Relevance 0.18

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