INT13717

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Context Info
Confidence 0.40
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.64
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TYMS) mitochondrion (TYMS) small molecule metabolic process (TYMS)
aging (TYMS) cytoplasm (TYMS) cytosol (TYMS)
TYMS (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 6 93.56 High High
methotrexate 1 79.04 Quite High
Pain 3 30.88 Quite Low
Sicca syndrome 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wound Healing 2 99.16 Very High Very High Very High
Mesothelioma 47 99.04 Very High Very High Very High
Cancer 7 88.24 High High
Toxicity 7 88.16 High High
Disease 22 84.44 Quite High
Uveitis 1 83.08 Quite High
Leukemia 1 82.76 Quite High
Adhesions 6 58.72 Quite High
Injury 2 48.56 Quite Low
Ulcers 1 45.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of Ts activity displayed a bimodal response at concentrations between 10(-12) to 10(-13) M and 10(-9) to 10(-10) M, while the induction of Th activity was consistently observed at 10(-11) M.
Positive_regulation (induction) of Ts
1) Confidence 0.40 Published 1991 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 1676942 Disease Relevance 0 Pain Relevance 0.45
More recently, the novel antifolate pralatrexate demonstrated activity in preclinical models, but not in a phase II trial in mesothelioma patients [16].The only FDA-approved agent for mesothelioma is pemetrexed, an antifolate which principally targets thymidylate synthase, as well as dihydrofolate reductase and glycinamide ribonucleotide formyltransferase.
Positive_regulation (targets) of thymidylate synthase associated with mesothelioma
2) Confidence 0.14 Published 2008 Journal Curr Treat Options Oncol Section Body Doc Link PMC2782121 Disease Relevance 1.19 Pain Relevance 0.04
A significant increase in epidermal growth factor receptor levels are also found in peripheral tissues of males, as compared to females [43]; and d) thymidylate synthetase, an enzyme that promotes DNA synthesis and repair [41].
Positive_regulation (increase) of thymidylate synthetase
3) Confidence 0.10 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790476 Disease Relevance 0.45 Pain Relevance 0

General Comments

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