INT137175

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.32
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL9) extracellular space (CXCL9) extracellular region (CXCL9)
cell-cell signaling (CXCL9)
Anatomy Link Frequency
synovial fluids 2
CXCL9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 2 99.68 Very High Very High Very High
Arthritis 10 99.18 Very High Very High Very High
spinal inflammation 2 98.72 Very High Very High Very High
Etanercept 2 98.02 Very High Very High Very High
chemokine 12 93.24 High High
cytokine 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 2 99.68 Very High Very High Very High
Seronegative Spondarthritis 2 99.18 Very High Very High Very High
Low Back Pain 2 98.72 Very High Very High Very High
Spondylarthropathies 2 98.18 Very High Very High Very High
Arthritis 8 95.80 Very High Very High Very High
Necrosis 2 86.84 High High
Cancer 2 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In synovial fluids of patients with spondylarthropathies (ie ankylosing spondylitis or psoriatic arthritis) or rheumatoid arthritis, significantly enhanced CXCL9, but not CXCL11 levels, were detected compared to concentrations in synovial fluids of patients with metabolic crystal-induced arthritis.
Positive_regulation (enhanced) of Gene_expression (levels) of CXCL9 in synovial fluids associated with seronegative spondarthritis, spinal inflammation, rheumatoid arthritis, spondylarthropathies and arthritis
1) Confidence 0.47 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.71 Pain Relevance 0.54
Etanercept, a humanized soluble recombinant p75 TNF-receptor/IgG(1)Fc fusionprotein, neutralized synergistic CXCL9 production induced by TNF-alpha plus IFN-gamma, but not synergy between IFN-gamma and the TLR ligands PGN or LPS.
Positive_regulation (induced) of Gene_expression (production) of CXCL9 associated with etanercept
2) Confidence 0.38 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.61 Pain Relevance 0.53

General Comments

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