INT137178
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
TLR3 and TLR4 mRNA expression varied significantly between control, hyperplasia and endometrial adenocarcinoma samples (Kruskal-Wallis test, P < 0.01). | |||||||||||||||
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Indeed, the TLR3 receptor was found to be locally expressed in a subset of epithelial cells within one gland. | |||||||||||||||
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TLR3 and TLR4 proteins were expressed mainly in the luminal and glandular epithelium (figure 2). | |||||||||||||||
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TLR3 and TLR4 expression is deregulated in peritoneal endometriosis | |||||||||||||||
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Interestingly, Th2 cytokines were shown to play an important role in balancing TLR signalling in human intestinal epithelial cells by mediating downregulation of TLR3 and TLR4 expression and function [42]. | |||||||||||||||
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In the current study, we report that toll-like receptor 3 and 4 expression is modulated in pathogenic alterations of the endometrium. | |||||||||||||||
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TLR3 and TLR4 are expressed in postmenopausal endometrium and regulated endometrial adenocarcinoma | |||||||||||||||
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Figure 4 exemplary presents the expression of TLR3 and TLR4 protein in eutopic compared to ectopic endometrium from the same patient. | |||||||||||||||
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For the first time, we present endometrial effluents expressing high levels of TLR3 and TLR4 proteins. | |||||||||||||||
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In endometriosis, we can observe a significant decrease in TLR3 and TLR4 mRNA levels in eutopic tissues collected during the proliferative phase, when compared to controls (P < 0.05; figure 3AB). | |||||||||||||||
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In undifferentiated G3 carcinoma, TLR3 and TLR4 mRNA levels were significantly lower than in postmenopausal controls (P < 0.01) and in hyperplasic endometrial tissues (P < 0.05, figure 5CD). | |||||||||||||||
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In undifferentiated G3 carcinoma, staining for TLR3 (figure 6E) and TLR4 (figure 6J) was not detectable, strengthening our findings of low TLR3 and TLR4 mRNA abundance in G3 carcinoma (figure 5B). | |||||||||||||||
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For the first time, we present endometrial effluents expressing high levels of TLR3 and TLR4 proteins. | |||||||||||||||
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The increased expression of TLR2, TLR3 and TLR4 as a consequence of allergen exposure is in line with a previous report demonstrating an increase of TLR2 protein in chronic middle ear inflammation [26]. | |||||||||||||||
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In patients with peritoneal endometriosis, TLR3 and TLR4 mRNA expression decreased significantly in proliferative diseased endometrium compared to controls. | |||||||||||||||
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In most tissues including gut, gonads and placenta, TLR3 is greater expressed than TLR4 mRNA [32]. | |||||||||||||||
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TLR3 and TLR4 expression was investigated during the menstrual cycle and in postmenopausal endometrium considering peritoneal endometriosis, hyperplasia, and endometrial adenocarcinoma specimens (grade 1 to 3). | |||||||||||||||
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TLR3 and TLR4 expression in healthy and diseased human endometrium
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Healthy and differentiated endometrium seems to require an adequate TLR3 and TLR4 expression. | |||||||||||||||
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However, peptidoglycan (PGN), double-stranded (ds) RNA or lipopolysaccharide (LPS) (TLR2, TLR3 or TLR4 ligands, respectively) synergized with interferon-gamma (IFN-gamma) at inducing CXCL9 and CXCL10. | |||||||||||||||
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General Comments
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