INT137180

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.24
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CXCR3) plasma membrane (CXCR3) cytoplasm (CXCR3)
signal transducer activity (CXCR3)
Anatomy Link Frequency
bladder 2
T-cell 2
blood 1
monocytes 1
endothelial cells 1
CXCR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 212 99.96 Very High Very High Very High
cytokine 103 99.84 Very High Very High Very High
Inflammation 101 99.56 Very High Very High Very High
Arthritis 105 98.36 Very High Very High Very High
interstitial cystitis 6 96.44 Very High Very High Very High
rheumatoid arthritis 50 92.16 High High
spinal inflammation 20 91.84 High High
agonist 2 81.28 Quite High
cINOD 3 71.04 Quite High
antagonist 8 68.48 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 105 99.56 Very High Very High Very High
Atherosclerosis 102 99.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 40 98.36 Very High Very High Very High
Arthritis 47 97.92 Very High Very High Very High
Interstitial Cystitis 6 96.44 Very High Very High Very High
Rheumatic Diseases 3 94.48 High High
Rheumatoid Arthritis 54 92.16 High High
Low Back Pain 20 91.84 High High
Seronegative Spondarthritis 18 91.52 High High
Injury 4 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative real-time polymerase chain reaction confirmed increased mRNA expression of several genes in the bladder samples of patients with ulcerative interstitial cystitis, including CXCR3 binding chemokines (CXCL9, 10 and 11) and TNFSF14 (LIGHT).
CXCR3 Binding (binding) of in bladder
1) Confidence 0.41 Published 2010 Journal J. Urol. Section Body Doc Link 20096889 Disease Relevance 0 Pain Relevance 0
The chemokine receptor CXCR3 is expressed mainly on activated T lymphocytes and binds three pro-inflammatory, interferon-gamma-inducible chemokines: monokine induced by IFN-gamma (Mig/CXCL9), IFN-gamma-induced protein-10 (IP-10/CXCL10) and IFN-gamma-inducible T-cell alpha-chemoattractant (I-TAC/CXCL11).
CXCR3 Binding (binds) of in T-cell associated with chemokine and inflammation
2) Confidence 0.36 Published 2010 Journal Methods Mol. Biol. Section Abstract Doc Link 20379873 Disease Relevance 0.40 Pain Relevance 0.50
CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative interstitial cystitis.
CXCR3 Binding (binding) of in bladder associated with chemokine and interstitial cystitis
3) Confidence 0.32 Published 2010 Journal J. Urol. Section Title Doc Link 20096889 Disease Relevance 0.10 Pain Relevance 0.24
CONCLUSIONS: Our study using DNA microarray analysis followed by quantitative real-time polymerase chain reaction reveals over expression of genes related to immune and inflammatory responses, including T-helper type 1 related chemokines, and cytokines such as CXCR3 binding chemokines and TNFSF14.
CXCR3 Binding (binding) of
4) Confidence 0.30 Published 2010 Journal J. Urol. Section Body Doc Link 20096889 Disease Relevance 0 Pain Relevance 0
TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis.
CXCR3 Binding (ligands) of in endothelial cells associated with arthritis and cytokine
5) Confidence 0.30 Published 2006 Journal Lab. Invest. Section Title Doc Link 16847431 Disease Relevance 0.30 Pain Relevance 0.28
that binds to the CXCR3 receptor on T lymphocytes at the atherosclerotic lesion [49].
CXCR3 receptor Binding (binds) of in T lymphocytes associated with atherosclerosis
6) Confidence 0.26 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.61 Pain Relevance 0.20
Enhanced levels of CXCR3 ligands in rheumatic disorders
CXCR3 Binding (ligands) of
7) Confidence 0.21 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.81 Pain Relevance 0.47
-induced protein (IP)-10), a ligand for CXCR3, are expressed in the inflamed joint in JIA at higher levels than in peripheral blood.
CXCR3 Binding (ligand) of in blood associated with arthritis
8) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.99 Pain Relevance 0.69
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
CXCR3 Binding (ligand) of in monocytes
9) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.58
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
CXCR3 Binding (ligand) of in fibroblasts
10) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.58

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