INT137181

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 13.09
Pain Relevance 9.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL9) extracellular space (CXCL9) extracellular region (CXCL9)
cell-cell signaling (CXCL9)
Anatomy Link Frequency
synovial fluids 3
T lymphocytes 3
brain 2
blood 2
monocytes 2
CXCL9 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 469 100.00 Very High Very High Very High
chemokine 385 100.00 Very High Very High Very High
Inflammation 263 100.00 Very High Very High Very High
Arthritis 71 99.84 Very High Very High Very High
rheumatoid arthritis 310 99.68 Very High Very High Very High
spinal inflammation 3 98.54 Very High Very High Very High
Etanercept 6 98.02 Very High Very High Very High
Central nervous system 46 97.32 Very High Very High Very High
metalloproteinase 32 94.52 High High
Inflammatory response 48 94.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 335 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 21 99.84 Very High Very High Very High
Rheumatoid Arthritis 310 99.68 Very High Very High Very High
Hypersensitivity 11 99.68 Very High Very High Very High
Contact Dermatitis 28 99.50 Very High Very High Very High
Seronegative Spondarthritis 4 99.00 Very High Very High Very High
Low Back Pain 3 98.54 Very High Very High Very High
Spondylarthropathies 3 98.00 Very High Very High Very High
Arthritis 46 96.40 Very High Very High Very High
Osteoarthritis 56 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced chemokines CXCL9/MIG and CXCL10/IP10 were elevated, albeit to varying degrees, in sera from FP (Figure 4C and Additional File 4, Table S3).
Gene_expression (elevated) of CXCL9 associated with chemokine
1) Confidence 0.65 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.37 Pain Relevance 0.58
-induced chemokines CXCL9/MIG and CXCL10/IP10 were elevated, albeit to varying degrees, in sera from FP (Figure 4C and Additional File 4, Table S3).
Gene_expression (elevated) of MIG associated with chemokine
2) Confidence 0.65 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.37 Pain Relevance 0.58
, IL-2, IL-4, IL-5, IL-13, IL-17, MIG, and IP-10) were excluded from our analysis due to weak signal in both pre- and post- S. aureus stimulated supernatant (5 cytokines); lack of response to S. aureus (2 cytokines), and cross-contamination (2 cytokines) (Figure S5).
Gene_expression (cross) of MIG associated with cytokine
3) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0 Pain Relevance 0.53
, IL-2, IL-4, IL-5, IL-13, IL-17, MIG, and IP-10) were excluded from our analysis due to weak signal in both pre- and post- S. aureus stimulated supernatant (5 cytokines); lack of response to S. aureus (2 cytokines), and cross-contamination (2 cytokines) (Figure S5).
Neg (lack) Gene_expression (excluded) of MIG associated with cytokine
4) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0 Pain Relevance 0.51
Etanercept, a humanized soluble recombinant p75 TNF-receptor/IgG(1)Fc fusionprotein, neutralized synergistic CXCL9 production induced by TNF-alpha plus IFN-gamma, but not synergy between IFN-gamma and the TLR ligands PGN or LPS.
Gene_expression (production) of CXCL9 associated with etanercept
5) Confidence 0.63 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.61 Pain Relevance 0.53
In synovial fluids of patients with spondylarthropathies (ie ankylosing spondylitis or psoriatic arthritis) or rheumatoid arthritis, significantly enhanced CXCL9, but not CXCL11 levels, were detected compared to concentrations in synovial fluids of patients with metabolic crystal-induced arthritis.
Gene_expression (detected) of CXCL9 in synovial fluids associated with seronegative spondarthritis, spinal inflammation, rheumatoid arthritis, spondylarthropathies and arthritis
6) Confidence 0.63 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.71 Pain Relevance 0.54
In synovial fluids of patients with spondylarthropathies (ie ankylosing spondylitis or psoriatic arthritis) or rheumatoid arthritis, significantly enhanced CXCL9, but not CXCL11 levels, were detected compared to concentrations in synovial fluids of patients with metabolic crystal-induced arthritis.
Gene_expression (levels) of CXCL9 in synovial fluids associated with seronegative spondarthritis, spinal inflammation, rheumatoid arthritis, spondylarthropathies and arthritis
7) Confidence 0.63 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.71 Pain Relevance 0.54
Furthermore, neuroinvasion was accompanied by the appearance of the proinflammatory chemokines CXCL9/MIG and CCL2/MCP-1 in the brain.
Gene_expression (appearance) of CXCL9 in brain associated with chemokine
8) Confidence 0.58 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.59 Pain Relevance 0.10
Furthermore, neuroinvasion was accompanied by the appearance of the proinflammatory chemokines CXCL9/MIG and CCL2/MCP-1 in the brain.
Gene_expression (appearance) of MIG in brain associated with chemokine
9) Confidence 0.58 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.60 Pain Relevance 0.10
Since the AMC was elevated in FP blood and monocytes produce, among others, IL6, CXCL9/MIG and CXCL10/IP10, we questioned if cytokine production by isolated PBMC could reflect the cytokine profiles observed in sera.
Gene_expression (produce) of CXCL9 in monocytes associated with cytokine
10) Confidence 0.58 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.73 Pain Relevance 0.51
On the other hand, right branch shows overexpression areas with genes such as CASP 10, CD30-L, and CD-40-L (TNF family), ras-like small, FGF 3 and 5, TDGF1, ERK5, MIF, IFNGR2, MIG, IFN-alpha, beta, gamma, IL-3, -4, -9 and -13, IP-10, HPRT, DCC, TEK, netrin-2, cadherins 4, 8, 12 and 13 [33], MMP3, 8, 10, 12 and 13 (metalloproteinase), COL11A2, CCNG1, CDC-6, ATM, N-MYC, and p53.
Gene_expression (overexpression) of MIG in TEK associated with metalloproteinase
11) Confidence 0.39 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.67 Pain Relevance 0.05
Both the residual synovial-lining cells and infiltrating leukocytes are the source of pro-inflammatory chemokines such as CCL2, CCL3, CCL5, CCL20, CXCL9 and CXCL10, as well as chemokines important for the homeostasis of lymphocytes, such as CXCL12 and CXCL13 [2,9-13].
Gene_expression (source) of CXCL9 in lymphocytes associated with chemokine and inflammation
12) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.76 Pain Relevance 0.76
(MIG), CXCL10/IFN-?
Gene_expression (/) of MIG
13) Confidence 0.36 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.27 Pain Relevance 0.43
To monitor also the innate response to dsRNAs, we concentrated on the rapid innate production of CXCL9 (MIG) and CXCL10 (IP-10) chemokines, which are induced by dsRNA [52] as well as CCL21 (SLC), which attracts naïve T lymphocytes and DCs [53].
Gene_expression (production) of MIG in T lymphocytes associated with chemokine
14) Confidence 0.34 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.39 Pain Relevance 0.05
To monitor also the innate response to dsRNAs, we concentrated on the rapid innate production of CXCL9 (MIG) and CXCL10 (IP-10) chemokines, which are induced by dsRNA [52] as well as CCL21 (SLC), which attracts naïve T lymphocytes and DCs [53].
Gene_expression (production) of CXCL9 in T lymphocytes associated with chemokine
15) Confidence 0.34 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.39 Pain Relevance 0.05
Expression of CXCL9 and CXCL10 was primarily in the T cell areas of the draining lymph node.
Gene_expression (Expression) of CXCL9 in T cell
16) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.14 Pain Relevance 0.12
Injection of dsRNA led to increased numbers of cells producing the T cell–activating chemokines CXCL9 and CXCL10 as detected by in situ hybridization in draining lymph nodes 18 hours after injections, and to increased serum levels of CXCL10 (p?
Gene_expression (producing) of CXCL9 in lymph nodes associated with chemokine
17) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2660151 Disease Relevance 0.46 Pain Relevance 0.13
Since the AMC was elevated in FP blood and monocytes produce, among others, IL6, CXCL9/MIG and CXCL10/IP10, we questioned if cytokine production by isolated PBMC could reflect the cytokine profiles observed in sera.
Gene_expression (produce) of MIG in monocytes associated with cytokine
18) Confidence 0.26 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.73 Pain Relevance 0.51
Since the AMC was elevated in FP blood and monocytes produce, among others, IL6, CXCL9/MIG and CXCL10/IP10, we questioned if cytokine production by isolated PBMC could reflect the cytokine profiles observed in sera.
Gene_expression (produce) of CXCL9 in blood associated with cytokine
19) Confidence 0.20 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.73 Pain Relevance 0.51
, MIG, and MIF production by lung parenchyma (n = 6 different preparations) and TNF-?
Gene_expression (production) of MIG in parenchyma
20) Confidence 0.16 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0 Pain Relevance 0.37

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