INT137183

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.38
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL11) extracellular space (CXCL11) extracellular region (CXCL11)
cell-cell signaling (CXCL11)
Anatomy Link Frequency
macrophage 2
blood 2
synovial fluids 2
CXCL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 99.68 Very High Very High Very High
Arthritis 6 99.18 Very High Very High Very High
spinal inflammation 1 98.72 Very High Very High Very High
chemokine 23 97.84 Very High Very High Very High
fibrosis 3 85.76 High High
Etanercept 1 80.04 Quite High
cytokine 14 75.00 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1 99.68 Very High Very High Very High
Seronegative Spondarthritis 1 99.18 Very High Very High Very High
Sarcoidosis 40 99.08 Very High Very High Very High
Low Back Pain 1 98.72 Very High Very High Very High
Spondylarthropathies 1 98.18 Very High Very High Very High
Fever 17 97.48 Very High Very High Very High
Arthritis 5 95.80 Very High Very High Very High
Syndrome 19 94.88 High High
Dengue 126 87.76 High High
Infection 69 86.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of IP-10 and I-TAC in the peripheral blood of ten patients at the early onset of fever was confirmed by ELISA.
Positive_regulation (Increased) of Gene_expression (expression) of I-TAC in blood associated with fever
1) Confidence 0.45 Published 2007 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2100376 Disease Relevance 1.31 Pain Relevance 0.05
In synovial fluids of patients with spondylarthropathies (ie ankylosing spondylitis or psoriatic arthritis) or rheumatoid arthritis, significantly enhanced CXCL9, but not CXCL11 levels, were detected compared to concentrations in synovial fluids of patients with metabolic crystal-induced arthritis.
Positive_regulation (enhanced) of Gene_expression (levels) of CXCL11 in synovial fluids associated with seronegative spondarthritis, spinal inflammation, rheumatoid arthritis, spondylarthropathies and arthritis
2) Confidence 0.44 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.71 Pain Relevance 0.54
In contrast to our negative findings regarding macrophage polarization, previous studies have demonstrated higher expression of the M1 markers CXCL10 [6], CXCL11 [7] and CXCL16 [8] in sarcoidosis patients compared to healthy subjects.
Positive_regulation (demonstrated) of Gene_expression (expression) of CXCL11 in macrophage associated with sarcoidosis
3) Confidence 0.26 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.36 Pain Relevance 0.11

General Comments

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