INT1372

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 5
Speculated 4
Reported most in Abstract
Documents 50
Total Number 55
Disease Relevance 5.76
Pain Relevance 9.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
blood 10
renal nerve 10
nerve 9
sympathetic nervous system 6
plasma 4
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 32 100.00 Very High Very High Very High
agonist 28 100.00 Very High Very High Very High
narcan 24 100.00 Very High Very High Very High
anesthesia 23 100.00 Very High Very High Very High
opiate 15 100.00 Very High Very High Very High
Clonidine 11 100.00 Very High Very High Very High
Dopamine 8 100.00 Very High Very High Very High
Endogenous opioid 7 100.00 Very High Very High Very High
Serotonin 4 100.00 Very High Very High Very High
Calcium channel 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 1 99.98 Very High Very High Very High
Disease 6 98.60 Very High Very High Very High
Hypertension 100 98.34 Very High Very High Very High
INFLAMMATION 13 98.32 Very High Very High Very High
Hypotension 7 98.32 Very High Very High Very High
Neuropathic Pain 8 98.20 Very High Very High Very High
Pressure Volume 2 Under Development 22 96.60 Very High Very High Very High
Syndrome 27 94.16 High High
Postural Orthostatic Tachycardia Syndrome 85 93.44 High High
Increased Venous Pressure Under Development 24 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence for a role of dopamine and endogenous opioids in the control of the secretion of renin and adrenal steroids was sought in man.
Regulation (control) of Localization (secretion) of renin associated with dopamine and endogenous opioid
1) Confidence 0.62 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 7030527 Disease Relevance 0 Pain Relevance 0.38
Adrenergic regulation of renin secretion and renal hemodynamics during deliberate hypotension in humans.
Regulation (regulation) of Localization (secretion) of renin associated with hypotension
2) Confidence 0.61 Published 1993 Journal Am. J. Physiol. Section Title Doc Link 8238548 Disease Relevance 0.25 Pain Relevance 0.31
These results suggest that 1) norepinephrine released from nerve terminals may regulate active renin secretion early during development; 2) the effect of veratridine on active renin secretion was similar in fetal, newborn, and adult sheep; 3) veratridine had no significant effect on inactive renin secretion; and 4) active renin secretion due to depolarization of nerve terminals in fetal sheep is dependent on activation of beta-adrenoceptors as it is in adults.
Neg (no) Regulation (effect) of Localization (secretion) of renin in nerve
3) Confidence 0.61 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2679151 Disease Relevance 0 Pain Relevance 0.17
These data suggest that endogenous opioid peptides are modulators in the control of renin release and may be important participants in the pathogenesis of hypertension.
Regulation (control) of Localization (release) of renin associated with hypertension and endogenous opioid
4) Confidence 0.61 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3515972 Disease Relevance 0.19 Pain Relevance 0.68
Effect of dopamine on renin secretion in the anesthetized dog.
Regulation (Effect) of Localization (secretion) of renin associated with anesthesia and dopamine
5) Confidence 0.61 Published 1975 Journal Eur. J. Pharmacol. Section Title Doc Link 1175682 Disease Relevance 0.24 Pain Relevance 0.31
Despite the widespread use of furosemide in the treatment of various fluid and electrolyte disorders in the preterm and term human infant and child, the physiological effects of this potent diuretic agent on renal function and renin release during postnatal maturation are poorly understood.
Regulation (effects) of Localization (release) of renin
6) Confidence 0.60 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 7600440 Disease Relevance 0 Pain Relevance 0.11
There is an influence of the sympathetic system which could directly interact with aldosterone secretion from the adrenal gland, although renin release is also regulated by this system via ?
Regulation (regulated) of Localization (release) of renin in adrenal gland
7) Confidence 0.60 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC280657 Disease Relevance 0.07 Pain Relevance 0
The effect of phenylephrine on renin release was abolished by the intrarenal infusion of the alpha-antagonist phentolamine (50 micrograms/min), but was not affected by the intravenous administration of the PG synthetase inhibitor indomethacin (5 mg/kg).
Regulation (effect) of Localization (release) of renin associated with antagonist
8) Confidence 0.60 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6200712 Disease Relevance 0 Pain Relevance 0.09
We conclude that the sinus reflex arc affecting renin release involves not only activation of peripheral alpha- and beta-adrenergic receptors in the kidney but also inhibition of central alpha-adrenergic receptors.
Regulation (affecting) of Localization (release) of renin in kidney associated with aids-related complex
9) Confidence 0.59 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7039357 Disease Relevance 0.27 Pain Relevance 0.15
Experiments were conducted to examine the effects of prenalterol on renal function and renin secretion in anesthetized dogs.
Spec (examine) Regulation (effects) of Localization (secretion) of renin
10) Confidence 0.59 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6206317 Disease Relevance 0.06 Pain Relevance 0.04
Effects of a beta 1-adrenoceptor agonist, prenalterol, on renal function and renin secretion rate in anesthetized dogs.
Regulation (Effects) of Localization (secretion) of renin associated with anesthesia and agonist
11) Confidence 0.59 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 6206317 Disease Relevance 0.07 Pain Relevance 0.15
The effects of intrarenally infused phentolamine (5 micrograms/kg/min) on renin and prostaglandin E2 release induced by renal nerve stimulation (RNS, 2.5-5 Hz) were studied in indomethacin (5 mg/kg i.v.)
Regulation (effects) of Localization (release) of renin in renal nerve
12) Confidence 0.58 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6325667 Disease Relevance 0 Pain Relevance 0
In normotensive and hypertensive humans, prostaglandins, particularly PGE2 and PGI2, affect blood pressure through control of vascular resistance, salt excretion, cardiac output, and renin secretion.
Regulation (control) of Localization (secretion) of renin in blood associated with hypertension
13) Confidence 0.57 Published 1985 Journal Adv. Prostaglandin Thromboxane Leukot. Res. Section Abstract Doc Link 3159200 Disease Relevance 0.41 Pain Relevance 0.11
Effect of selective inhibition of the inducible cyclooxygenase on renin release in healthy volunteers.
Regulation (Effect) of Localization (release) of renin
14) Confidence 0.56 Published 1998 Journal J. Investig. Med. Section Title Doc Link 9737091 Disease Relevance 0.10 Pain Relevance 0.20
The role of renal nerves and norepinephrine release on renin secretion during fetal and postnatal maturation has not been studied.
Regulation (role) of Localization (secretion) of renin in renal nerves
15) Confidence 0.45 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2679151 Disease Relevance 0 Pain Relevance 0
Effects of carotid occlusion and clonidine on renin secretion in anaesthetized dogs.
Regulation (Effects) of Localization (secretion) of renin associated with clonidine
16) Confidence 0.45 Published 1976 Journal Clin Sci Mol Med Suppl Section Title Doc Link 1071584 Disease Relevance 0 Pain Relevance 0.27
Moreover, our data obtained in humans appear to confirm the co-regulatory interaction of COX-2 and angiotensin II in the control of renin release, as suggested by animal studies.


Regulation (control) of Localization (release) of renin
17) Confidence 0.44 Published 2001 Journal Swiss Med Wkly Section Body Doc Link 11345810 Disease Relevance 0 Pain Relevance 0
Inhibition of cyclooxygenase-2: effects on renin secretion and expression in fetal lambs.
Regulation (effects) of Localization (secretion) of renin associated with cox2
18) Confidence 0.41 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 12456386 Disease Relevance 0 Pain Relevance 0.19
Effects of K-351 (3,4-dihydro-8-(2-hydroxy-3-isopropyl-aminopropoxy)-3-nitroxy++ +-2H-1-benzopyran) on hemodynamics and renin release were investigated in pentobarbital anesthetized dogs.
Spec (investigated) Regulation (Effects) of Localization (release) of renin
19) Confidence 0.39 Published 1984 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6149735 Disease Relevance 0.14 Pain Relevance 0
The observation, made by others, of decreasing serum renin levels after large-volume paracentesis supports the importance of this effect, because renin secretion is controlled by transmural arteriolar pressure [24] and hypoperfusion at the macula densa [25], both probably influenced by changes in intra-abdominal or retroperitoneal pressure.
Regulation (controlled) of Localization (secretion) of renin in macula densa
20) Confidence 0.39 Published 2008 Journal Crit Care Section Body Doc Link PMC2374626 Disease Relevance 0.15 Pain Relevance 0

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