INT137207

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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.69
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf, Nfkb1) mitochondrion (Nfkb1) intracellular (Tnf)
DNA binding (Nfkb1) extracellular matrix organization (Tnf) protein complex (Nfkb1)
Anatomy Link Frequency
spinal 1
Tnf (Rattus norvegicus)
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 10 100.00 Very High Very High Very High
c fibre 5 100.00 Very High Very High Very High
spinal dorsal horn 2 100.00 Very High Very High Very High
Inflammatory stimuli 1 100.00 Very High Very High Very High
cytokine 4 99.96 Very High Very High Very High
Hippocampus 1 97.68 Very High Very High Very High
Inflammation 12 97.48 Very High Very High Very High
Chronic pancreatitis 1 93.92 High High
Pain 1 84.92 Quite High
Inflammatory response 3 83.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 18 100.00 Very High Very High Very High
Nervous System Injury 12 100.00 Very High Very High Very High
Cancer 6 100.00 Very High Very High Very High
Necrosis 5 100.00 Very High Very High Very High
Pancreatic Cancer 7 99.36 Very High Very High Very High
Adenocarcinoma 1 95.12 Very High Very High Very High
Pancreatitis 1 93.92 High High
Neurological Disease 1 92.04 High High
Pain 1 84.92 Quite High
Neuropathic Pain 4 75.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of these cytokines, Tumor necrosis factor alpha (TNF-alpha), is known to induce nuclear factor kappab (NF-kappab) activation, a transcription factor that promotes further pro-inflammatory cytokine production in inflammatory cells [19].
Tumor necrosis factor alpha Positive_regulation (induce) of NF-kappab associated with necrosis, inflammation, cancer and cytokine
1) Confidence 0.23 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2607269 Disease Relevance 0.92 Pain Relevance 0.45
Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK.
Tumor necrosis factor-alpha Positive_regulation (induces) of NF-kappa B in spinal associated with c fibre, necrosis, nervous system injury, cancer, spinal dorsal horn and long-term potentiation
2) Confidence 0.19 Published 2007 Journal Neuropharmacology Section Title Doc Link 17084420 Disease Relevance 0.73 Pain Relevance 1.07
Further activation of NF-kappaB by inflammatory stimuli, including interleukin-1beta, tumor necrosis factor-alpha, and lipopolysaccharide, induced overexpression of Shh, resulting in activation of the Hh pathway.
tumor necrosis factor-alpha Positive_regulation (activation) of NF-kappaB associated with necrosis, cancer and inflammatory stimuli
3) Confidence 0.01 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16849549 Disease Relevance 1.05 Pain Relevance 0.19

General Comments

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