INT137223

Context Info Confidence 0.31 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.47 Pain Relevance 0.58

mitochondrion (Peo1) helicase activity (Peo1)

Anatomy Link Frequency poly 1 Peo1 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 4 99.26 agonist 1 95.92 Inflammation 28 83.52 cytokine 11 73.88 Inflammatory mediators 1 60.88 IPN 2 25.00 Crohn's disease 4 5.00 chemokine 3 5.00 Piles 2 5.00 aspirin 1 5.00

Disease Link Frequency Relevance Heat Pressure And Volume Under Development 4 98.70 Colitis 19 90.16 INFLAMMATION 27 83.52 Hyperplasia 1 38.68 Inflammatory Bowel Disease 38 6.00 Disease 15 5.00 Body Weight 5 5.00 Cancer 5 5.00 Hemorrhage 5 5.00 Toxicity 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The aim of this study was to investigate the mechanism of swelling, drug impregnation, and drug release from poly(ethylene oxide) (PEO) gel crosslinked by urethane bonds.

PEO Binding (crosslinked) of in poly associated with pressure and volume under development

1) Confidence 0.31 Published 2007 Journal J Pharm Sci Section Abstract Doc Link 17455363 Disease Relevance 0.10 Pain Relevance 0.14

This effect was particularly pronounced for acetaminophen due to its specific ability to form complexes with PEO.

PEO Binding (complexes) of associated with paracetamol

2) Confidence 0.31 Published 2007 Journal J Pharm Sci Section Abstract Doc Link 17455363 Disease Relevance 0.08 Pain Relevance 0.19

M PEO as compared to LPS activation alone (Table 5).

PEO Binding (compared) of

3) Confidence 0.27 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.30 Pain Relevance 0.25

Analysis of the complex plane and spectroscopic plots indicated the presence of two microscopic phases corresponding to the PEO-PU and PAN domains, which leads to space charge polarization in these systems.

PEO-PU Binding (leads) of

4) Confidence 0.06 Published 2005 Journal J Phys Chem B Section Abstract Doc Link 16851078 Disease Relevance 0 Pain Relevance 0

General Comments

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