INT137230

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.62
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trh, Oprd1) cytoplasm (Trh, Oprd1) extracellular region (Trh)
nucleus (Trh) signal transducer activity (Oprd1)
Anatomy Link Frequency
neurons 4
Trh (Rattus norvegicus)
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 8 100.00 Very High Very High Very High
opioid receptor 8 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Kappa opioid receptor 4 100.00 Very High Very High Very High
antagonist 8 96.72 Very High Very High Very High
narcan 2 94.96 High High
Morphine 6 93.80 High High
adenocard 14 80.88 Quite High
Opioid 4 66.56 Quite High
Disease Link Frequency Relevance Heat
Death 18 100.00 Very High Very High Very High
Hypothermia 2 97.28 Very High Very High Very High
Apoptosis 2 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, although [D-Ala(2), N-Me-Phe(4), Gly-ol(5)]-enkephalin (DAMGO; mu-opioid receptor agonist), [D-Pen(2,5)]-enkephalin (DPDPE; delta-opioid receptor agonist) and U-69593 (kappa-opioid receptor agonist) were also effective, LTCD of cultured hippocampal neurons was not affected by TRH.
TRH Neg (not) Regulation (affected) of Gene_expression (effective) of opioid receptor in neurons associated with kappa opioid receptor, agonist, opioid receptor, enkephalin and death
1) Confidence 0.01 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854391 Disease Relevance 0.80 Pain Relevance 1.36
In addition, although [D-Ala(2), N-Me-Phe(4), Gly-ol(5)]-enkephalin (DAMGO; mu-opioid receptor agonist), [D-Pen(2,5)]-enkephalin (DPDPE; delta-opioid receptor agonist) and U-69593 (kappa-opioid receptor agonist) were also effective, LTCD of cultured hippocampal neurons was not affected by TRH.
TRH Neg (not) Regulation (affected) of Gene_expression (effective) of opioid receptor in neurons associated with kappa opioid receptor, agonist, opioid receptor, enkephalin and death
2) Confidence 0.01 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854391 Disease Relevance 0.82 Pain Relevance 1.39

General Comments

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