INT13724

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.99
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (WT1) nucleolus (WT1) RNA binding (WT1)
nucleus (WT1) intracellular (WT1) cytoplasm (WT1)
Anatomy Link Frequency
testis 1
neuron 1
lining cells 1
WT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 99.98 Very High Very High Very High
cva 2 84.08 Quite High
Pain 4 83.40 Quite High
abdominal pain 1 76.16 Quite High
imagery 2 75.48 Quite High
pain flank 2 75.12 Quite High
peptic ulcer disease 1 75.00 Quite High
chemokine 8 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 55 99.76 Very High Very High Very High
Cyst 7 99.62 Very High Very High Very High
Myeloid Leukemia 41 98.44 Very High Very High Very High
Endodermal Sinus Tumor 1 96.64 Very High Very High Very High
Embryonal Carcinoma 1 95.56 Very High Very High Very High
Wilms Tumor 2 94.08 High High
Teratoma 2 93.20 High High
Disease 19 92.56 High High
Ulcers 4 90.44 High High
Recurrence 11 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The development of Wilms' tumor in the testis is rare and can be explained by the activation of the WT1 gene during embryogenesis.
Positive_regulation (activation) of WT1 gene in testis associated with cancer
1) Confidence 0.69 Published 2007 Journal Urology Section Abstract Doc Link 17656239 Disease Relevance 0.88 Pain Relevance 0.08
Immunostaining showed that the cyst lining cells were positive for keratin, vimentin, HBME-1, WT1, and thrombomodulin but negative for carcinoembryonic antigen, B72.3, Leu-M1, and BerEP4.
Positive_regulation (positive) of WT1 in lining cells associated with cyst
2) Confidence 0.41 Published 2000 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 10782166 Disease Relevance 0.79 Pain Relevance 0.26
Oka et al. investigated the effect of WT1 peptide vaccination in 26 cancer patients, including 13 patients with de novo AML [84].
Spec (investigated) Positive_regulation (vaccination) of WT1 associated with myeloid leukemia and cancer
3) Confidence 0.39 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 1.10 Pain Relevance 0
Immunohistochemically, the tumor cells were positive for anti-epithelial membrane antigen, vimentin, desmin, neuron-specific enolase and WT1 protein antibodies.
Positive_regulation (positive) of WT1 in neuron associated with cancer
4) Confidence 0.20 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10849332 Disease Relevance 0.98 Pain Relevance 0.08
The use of prophylactic cytoprotective prostaglandins (misoprostol) reduces the incidence of NSAID-induced GUD.
Positive_regulation (induced) of GUD associated with cinod
5) Confidence 0.04 Published 1991 Journal Med. Clin. North Am. Section Abstract Doc Link 1677060 Disease Relevance 1.24 Pain Relevance 0.17

General Comments

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