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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.38
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
spinal 1
Slc6a14 (Rattus norvegicus)
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 2 90.76 High High
antinociception 1 86.76 High High
withdrawal 1 75.32 Quite High
Pain 2 73.24 Quite High
spastic colon 3 67.56 Quite High
Inflammation 4 55.00 Quite High
diclofenac 2 50.00 Quite Low
Analgesic 1 25.00 Low Low
COX2 1 10.00 Low Low
cOX1 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 98.80 Very High Very High Very High
Colitis 1 95.20 Very High Very High Very High
Hypersensitivity 4 94.28 High High
Pain 1 73.24 Quite High
Nociception 1 64.64 Quite High
INFLAMMATION 5 58.04 Quite High
Functional Bowel Disorder 1 53.72 Quite High
Enteropathy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Colonic cyclooxygenase-2 and interkeukin-1beta mRNA and spinal c-FOS mRNA expression were significantly down-regulated by ATB-429, but not by mesalamine.
ATB-429 Negative_regulation (down-regulated) of cyclooxygenase-2 in spinal
1) Confidence 0.19 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16855178 Disease Relevance 0.73 Pain Relevance 0.58
ATB-337 inhibited cycloxygenase-1 and cyclooxygenase-2 activity as effectively as diclofenac.
ATB-337 Negative_regulation (inhibited) of cyclooxygenase-2
2) Confidence 0.03 Published 2007 Journal Gastroenterology Section Body Doc Link 17241876 Disease Relevance 0.06 Pain Relevance 0

General Comments

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