INT137262

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.45
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc18a2) aging (Slc18a2) enzyme binding (Slc18a2)
transmembrane transport (Slc18a2) cytoplasm (Slc18a2)
Anatomy Link Frequency
striatum 2
substantia nigra 1
juveniles 1
platelet 1
Slc18a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 37 100.00 Very High Very High Very High
monoamine 12 100.00 Very High Very High Very High
Substantia nigra 27 99.52 Very High Very High Very High
methadone 8 98.56 Very High Very High Very High
antidepressant 6 95.92 Very High Very High Very High
fluoxetine 4 87.24 High High
Opioid 2 86.48 High High
GABAergic 2 76.00 Quite High
tricyclic antidepressant 1 75.00 Quite High
sSRI 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Disease 220 91.08 High High
Sprains And Strains 6 90.60 High High
Toxicity 13 75.00 Quite High
Parkinson's Disease 100 67.48 Quite High
Neurologic Gait Disorders 4 50.36 Quite High
Syndrome 2 50.00 Quite Low
Hypokinesia 6 48.92 Quite Low
Tremor 6 42.28 Quite Low
Death 16 27.28 Quite Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased VMAT2 density may reflect a compensatory attempt to prevent vesicular depletion due to chronic methadone exposure.
Positive_regulation (increased) of VMAT2 associated with methadone
1) Confidence 0.68 Published 2007 Journal J Neural Transm Section Abstract Doc Link 16855915 Disease Relevance 0 Pain Relevance 0.61
In addition, VMAT2 levels were increased in juveniles.
Positive_regulation (increased) of VMAT2 in juveniles
2) Confidence 0.65 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19038246 Disease Relevance 0.31 Pain Relevance 0.63
A significant increase (19%, p < 0.05) in platelet VMAT2 density (Bmax) was observed in the methadone treated patients compared to controls.
Positive_regulation (increase) of VMAT2 in platelet associated with methadone
3) Confidence 0.49 Published 2007 Journal J Neural Transm Section Abstract Doc Link 16855915 Disease Relevance 0 Pain Relevance 0.63
They measured the expression and activity of the dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT2) in presynaptic terminals of dopaminergic neurons in the striatum.
Positive_regulation (activity) of VMAT2 in striatum associated with dopamine and monoamine
4) Confidence 0.28 Published 2010 Journal Neurology Research International Section Body Doc Link PMC2989867 Disease Relevance 0.51 Pain Relevance 0.31
They measured the expression and activity of the dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT2) in presynaptic terminals of dopaminergic neurons in the striatum.
Positive_regulation (activity) of monoamine transporter in striatum associated with dopamine and monoamine
5) Confidence 0.28 Published 2010 Journal Neurology Research International Section Body Doc Link PMC2989867 Disease Relevance 0.51 Pain Relevance 0.31
Methamphetamine reduced striatal dopamine and its metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid concentrations, striatal and substantia nigra dopamine and vesicular monoamine transporter specific binding as well substantia nigra dopamine and vesicular monoamine transporter mRNA levels and increased striatal preproenkephalin mRNA levels.
Positive_regulation (increased) of monoamine transporter mRNA in substantia nigra associated with dopamine, substantia nigra and monoamine
6) Confidence 0.25 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17825264 Disease Relevance 0.13 Pain Relevance 0.61

General Comments

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