INT137268

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.63
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 4
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 521 100.00 Very High Very High Very High
antagonist 4 99.84 Very High Very High Very High
Pain 9 94.76 High High
trigeminal ganglion 59 94.68 High High
Osteoarthritis 1 92.76 High High
Analgesic 2 70.32 Quite High
Sciatic nerve 78 68.00 Quite High
agonist 8 67.20 Quite High
Hyperalgesia 4 64.12 Quite High
Neuropathic pain 2 60.04 Quite High
Disease Link Frequency Relevance Heat
Cancer 1 95.80 Very High Very High Very High
Pain 10 94.76 High High
Ganglion Cysts 73 94.68 High High
Burns 1 93.76 High High
Osteoarthritis 1 92.76 High High
Cystitis 1 92.12 High High
Nervous System Injury 46 74.40 Quite High
Injury 107 68.52 Quite High
Hyperalgesia 8 64.12 Quite High
Neuropathic Pain 2 60.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical studies have shown that domain 5 of the TrkA (tropomyosin receptor kinase A) receptor is involved in the binding of NGF (nerve growth factor).
Regulation (involved) of nerve growth factor Binding (binding) of in nerve associated with nerve growth factor
1) Confidence 0.61 Published 2006 Journal Biochem. Soc. Trans. Section Abstract Doc Link 16856868 Disease Relevance 0 Pain Relevance 0.12
The Kd value for the binding of NAT-NGF and LBD-NGF was measured as 6.25×10?
Regulation (value) of NAT-NGF Binding (binding) of associated with nerve growth factor
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.14 Pain Relevance 1.08
Biochemical studies have shown that domain 5 of the TrkA (tropomyosin receptor kinase A) receptor is involved in the binding of NGF (nerve growth factor).
Regulation (involved) of NGF Binding (binding) of in nerve associated with nerve growth factor
3) Confidence 0.45 Published 2006 Journal Biochem. Soc. Trans. Section Abstract Doc Link 16856868 Disease Relevance 0 Pain Relevance 0.12
Effects of NGF, GDNF or BDNF treatment on TRPV1 mRNA and protein levels
Regulation (Effects) of NGF Binding (treatment) of associated with nerve growth factor
4) Confidence 0.43 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.33 Pain Relevance 0.39
The Kd value for the binding of NAT-NGF and LBD-NGF was measured as 6.25×10?
Regulation (value) of LBD-NGF Binding (binding) of associated with nerve growth factor
5) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.14 Pain Relevance 1.09
Other possible future therapies examined in this review include small-molecule TrkA antagonists, which target either the extracellular NGF binding domain of TrkA or its intracellular tyrosine kinase domain.
Regulation (target) of NGF Binding (binding) of associated with nerve growth factor and antagonist
6) Confidence 0.34 Published 2008 Journal BioDrugs Section Abstract Doc Link 18998753 Disease Relevance 1.02 Pain Relevance 1.11

General Comments

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