INT137270

Context Info Confidence 0.48 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 2.48 Pain Relevance 2.39

cytosol (PDE4D) signal transduction (PDE4D) cytoskeleton (PDE4D) microtubule organizing center (PDE4D) cytoplasm (PDE4D)

Anatomy Link Frequency filament 1 dental pulp 1 PDE4D (Homo sapiens)

Pain Link Frequency Relevance Heat pulpitis 18 99.90 Pain 231 99.44 burning pain 3 97.76 imagery 27 83.52 Neuropathic pain 48 78.60 backache 114 72.56 diabetic neuropathy 15 5.00 postherpetic neuralgia 13 5.00 Lasting pain 9 5.00 Analgesic 8 5.00

Disease Link Frequency Relevance Heat Pulpitis 18 99.90 Pain 231 99.44 Injury 4 98.56 Neuropathic Pain 78 78.60 Low Back Pain 118 72.56 Nerve Root Compression 2 72.00 Muscular Spasm 1 61.44 Increased Venous Pressure Under Development 1 59.32 Diabetic Neuropathy 15 5.00 Post Operative Pain 13 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results could point to a role of cAMP PDE in the initial pulp response after injury.

Positive_regulation (role) of cAMP PDE associated with injury

1) Confidence 0.48 Published 2004 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 16857100 Disease Relevance 0.63 Pain Relevance 0.53

In reversible pulpitis the cAMP PDE activity increased almost 2.5 times.

Positive_regulation (increased) of cAMP PDE associated with pulpitis

2) Confidence 0.48 Published 2004 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 16857100 Disease Relevance 0.55 Pain Relevance 0.55

High levels of cAMP PDE have been demonstrated to be in dental pulp cells.

Positive_regulation (levels) of cAMP PDE in dental pulp

3) Confidence 0.45 Published 2004 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 16857100 Disease Relevance 0.43 Pain Relevance 0.43

Items specific to the DN4 such as the test for a decreased pricking sensation after application of a von Frey filament of 5.1 g force were grouped with similar StEP items to mask their origin.

Positive_regulation (grouped) of DN4 in filament associated with pain

4) Confidence 0.07 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2661253 Disease Relevance 0.87 Pain Relevance 0.88

General Comments

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