INT137271

Context Info Confidence 0.29 First Reported 2004 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 1.95 Pain Relevance 1.53

cytosol (PDE6B) signal transduction (PDE6B)

Anatomy Link Frequency photoreceptor 1 dental pulp 1 PDE6B (Homo sapiens)

Pain Link Frequency Relevance Heat pulpitis 18 99.90 ketamine 2 5.00 Central nervous system 1 5.00 anesthesia 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Pulpitis 18 99.90 Injury 3 98.56 Retina Disease 13 97.96 Blindness 20 97.16 Disease 12 52.64 Ocular Toxicity (including Many Sub-types) 11 48.72 Retinal Diseases 7 30.72 Leber Congenital Amaurosis / Leber Congenital Amaurosis 17 5.00 Death 2 5.00 Urological Neuroanatomy 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results point to a role of cGMP PDE in the initial pulp response after injury.

Positive_regulation (role) of cGMP PDE associated with injury

1) Confidence 0.29 Published 2004 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 16857102 Disease Relevance 0.63 Pain Relevance 0.53

In reversible pulpitis the cGMP PDE activity increased almost 3 times.

Positive_regulation (increased) of cGMP PDE associated with pulpitis

2) Confidence 0.29 Published 2004 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 16857102 Disease Relevance 0.55 Pain Relevance 0.55

Mutations in the AIPL1 gene destabilize cGMP PDE and lead to photoreceptor dysfunction and a rapid retinal degeneration in mouse [8,9] and human [10].

Positive_regulation (destabilize) of cGMP PDE in photoreceptor associated with retina disease

3) Confidence 0.28 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1463903 Disease Relevance 0.33 Pain Relevance 0

High levels of cGMP PDE are found in dental pulp cells.

Positive_regulation (levels) of cGMP PDE in dental pulp

4) Confidence 0.27 Published 2004 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 16857102 Disease Relevance 0.44 Pain Relevance 0.44

General Comments

This test has worked.