INT137284

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Vkorc1) endoplasmic reticulum (Vkorc1)
Vkorc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
vincristine 3 98.86 Very High Very High Very High
Opioid 1 95.60 Very High Very High Very High
Analgesic 2 95.32 Very High Very High Very High
Central nervous system 1 95.08 Very High Very High Very High
antidepressant 1 94.84 High High
Peripheral nervous system 3 93.64 High High
addiction 3 82.68 Quite High
induced neuropathy 6 75.00 Quite High
Eae 2 75.00 Quite High
Peripheral nerve injury 1 60.88 Quite High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 2 96.60 Very High Very High Very High
Neuropathic Pain 6 75.00 Quite High
Injury 1 75.00 Quite High
Nervous System Injury 1 60.00 Quite High
Diabetic Nephropathy 4 57.92 Quite High
Inflammatory Pain 1 56.40 Quite High
Hemorrhage 5 17.48 Low Low
Adverse Drug Reaction 6 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 2 5.00 Very Low Very Low Very Low
Thrombosis Related Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of these SNPs is located in the promoter region and usually included in studies of the VKORC1 genetics and warfarin dose requirements, namely ?
Gene_expression (genetics) of VKORC1
1) Confidence 0.33 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958670 Disease Relevance 0 Pain Relevance 0.04
Vincristine treatment is responsible for the induction of multidrug resistance (MDR) gene expression and transporter activity, with deleterious consequences, including a potential decrease in the efficiency of opioid analgesics, antidepressants or antiepileptics.
Gene_expression (expression) of resistance associated with vincristine, antidepressant, analgesic and opioid
2) Confidence 0.05 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16859677 Disease Relevance 0.54 Pain Relevance 0.81

General Comments

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