INT13729

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Context Info
Confidence 0.62
First Reported 1989
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 0.59
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH, GH1) extracellular region (GHRH, GH1) cell-cell signaling (GHRH)
Anatomy Link Frequency
follicle 2
neural 2
GHRH (Homo sapiens)
GH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 2 100.00 Very High Very High Very High
antagonist 9 99.74 Very High Very High Very High
Clonidine 21 99.70 Very High Very High Very High
Somatostatin 14 99.68 Very High Very High Very High
agonist 10 99.42 Very High Very High Very High
Catecholamine 2 99.24 Very High Very High Very High
Opioid 3 99.16 Very High Very High Very High
narcan 2 99.04 Very High Very High Very High
cytokine 2 93.96 High High
Enkephalin 4 92.16 High High
Disease Link Frequency Relevance Heat
Syndrome 2 98.52 Very High Very High Very High
Hypoglycemia 3 98.32 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

2 91.96 High High
Growth Problems 3 77.36 Quite High
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Growth hormone-releasing hormone (GHRH) stimulates GH secretion in man and the hormonal response is specific.
Growth hormone-releasing hormone Positive_regulation (stimulates) of Localization (secretion) of GH
1) Confidence 0.62 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1901390 Disease Relevance 0.07 Pain Relevance 0.10
Growth hormone-releasing hormone (GHRH) stimulates GH secretion in man and the hormonal response is specific.
GHRH Positive_regulation (stimulates) of Localization (secretion) of GH
2) Confidence 0.62 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1901390 Disease Relevance 0.07 Pain Relevance 0.10
In eight normal volunteers subjects we compared the pattern of GHRH-induced GH release to that elicited by similar challenge given 60 min after a pretreatment with drugs affecting alpha 2-adrenergic and muscarinic cholinergic neurotransmission.
GHRH Positive_regulation (induced) of Localization (release) of GH
3) Confidence 0.54 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1677361 Disease Relevance 0 Pain Relevance 0.29
To throw further light on adrenergic neuroregulation of somatotrophic function in man, the effect of various catecholamine agonists and antagonists on basal or GHRH-stimulated GH secretion was studied.
GHRH Positive_regulation (stimulated) of Localization (secretion) of GH associated with antagonist, catecholamine and agonist
4) Confidence 0.47 Published 1990 Journal Endocrinol. Exp. Section Abstract Doc Link 1972919 Disease Relevance 0 Pain Relevance 0.68
Opioid-receptor blockade blunts growth hormone (GH) secretion induced by GH-releasing hormone in the human male.
GH-releasing hormone Positive_regulation (induced) of Localization (secretion) of GH associated with opioid
5) Confidence 0.43 Published 1998 Journal Horm. Metab. Res. Section Title Doc Link 9503036 Disease Relevance 0 Pain Relevance 0.25
The stimulatory effect of clonidine and L-dopa on GH release is mediated via GHRH.
GHRH Positive_regulation (mediated) of Localization (release) of GH associated with clonidine
6) Confidence 0.41 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1901390 Disease Relevance 0.18 Pain Relevance 0.15
In 10 normal volunteers subjects we compared the pattern of GHRH-induced GH release to that elicited by similar challenge given 60 min after a pretreatment with drugs affecting adrenergic and muscarinic cholinergic neurotransmission, both in basal situations and after having induced hypercortisolism.
GHRH-induced Positive_regulation (induced) of Localization (release) of GH
7) Confidence 0.37 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8094392 Disease Relevance 0 Pain Relevance 0.13
The adrenergic system is involved in the neural control of GH secretion with both stimulatory and inhibitory influences mainly mediated via GHRH and/or somatostatin modulation.
GHRH Positive_regulation (mediated) of Localization (secretion) of GH in neural associated with somatostatin
8) Confidence 0.34 Published 1990 Journal Endocrinol. Exp. Section Abstract Doc Link 1972919 Disease Relevance 0 Pain Relevance 0.53
Given that clonidine pretreatment induced a more physiological episodic pattern of GRF-induced GH release, the possibility of combining clonidine and GRF therapy for short stature in children is envisaged.


GRF-induced Positive_regulation (induced) of Localization (release) of GH
9) Confidence 0.24 Published 1991 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 1934527 Disease Relevance 0 Pain Relevance 0
Since the GHRH-(1-29)NH2 dose (100 micrograms) used was a maximally stimulatory one, these results suggest that the enhancing effect of G-DAMME on GHRH-induced GH release may be mediated through inhibition of somatostatin release.
GHRH-induced Positive_regulation (induced) of Localization (release) of GH associated with somatostatin
10) Confidence 0.24 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2546963 Disease Relevance 0 Pain Relevance 0.28
The normal GHRH-induced GH secretion was completely abolished in the Cushing's syndrome group.
GHRH-induced Positive_regulation (induced) of Localization (secretion) of GH associated with syndrome
11) Confidence 0.15 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2106087 Disease Relevance 0.20 Pain Relevance 0.22
The co-existence of pituitary hormone and neuropeptide secretion [growth hormone (GH), prolactin (PRL), adrenocorticotropic hormone (ACTH), thyroid stimulating hormone (TSH), triiodothyronine (T3), somatostatin, oxytocin (OT), follicle stimulating hormone (FSH), luteinizing hormone (LH), arginine vasopressin (AVP), growth hormone releasing hormone (GHRH), corticotropin releasing hormone (CRH), nerve growth factor (NGF), vasoactive intestinal peptide (VIP), pro-enkephalin (pro-enk), and beta-endorphin (beta-end)], as well as production of a number of interleukins and growth factors and expression of receptors for all, by RE cells is an unique molecular biological phenomenon.
growth hormone Positive_regulation (co-existence) of Localization (secretion) of GH in follicle associated with nerve growth factor, somatostatin, neuropeptide and enkephalin
12) Confidence 0.11 Published 2000 Journal Anticancer Res. Section Abstract Doc Link 10928121 Disease Relevance 0 Pain Relevance 0.27
OBJECTIVE: Growth hormone-releasing peptides (GHRPs) stimulate growth hormone (GH) release in vitro and in vivo in animals and in humans.
Growth hormone Positive_regulation (stimulate) of Localization (release) of GH
13) Confidence 0.08 Published 1995 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 7586608 Disease Relevance 0 Pain Relevance 0.20

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