INT13730

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Context Info
Confidence 0.35
First Reported 1981
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.78
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CHRM1) signal transduction (CHRM1) protein modification process (CHRM1)
plasma membrane (CHRM1) signal transducer activity (CHRM1)
Anatomy Link Frequency
acinar cells 1
glands 1
CHRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 100.00 Very High Very High Very High
Nicotine 2 99.98 Very High Very High Very High
tetrodotoxin 2 99.12 Very High Very High Very High
depression 1 98.48 Very High Very High Very High
opiate 2 97.16 Very High Very High Very High
agonist 1 96.72 Very High Very High Very High
Morphine 4 94.32 High High
cocaine 4 90.24 High High
Somatostatin 5 86.96 High High
Clonidine 5 68.24 Quite High
Disease Link Frequency Relevance Heat
Repression 28 99.16 Very High Very High Very High
Ulcers 3 98.60 Very High Very High Very High
Depression 1 98.48 Very High Very High Very High
Cancer 100 90.64 High High
Prostate Cancer 332 79.56 Quite High
Nicotine Addiction 4 75.00 Quite High
Pancreatitis 1 75.00 Quite High
Duodenal Ulcer 1 59.12 Quite High
Pain 1 48.96 Quite Low
Hypoxia 1 34.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pirenzepine, the first M1-receptor antagonist, has more selective inhibitory properties on oxyntic gastric glands and accelerates healing rates in peptic ulcer.
Negative_regulation (antagonist) of M1-receptor in glands associated with antagonist and ulcers
1) Confidence 0.35 Published 1986 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2881347 Disease Relevance 0.30 Pain Relevance 0.18
The four genes most strongly repressed in C4-2B cells – MUC6, CHRM1, KIAA1217, and WBSCR28 – were also repressed in LNCaP cells, but repression generally occurred faster in the C4-2B cells (Figure 2ZC, ZD, ZE, ZF).
Negative_regulation (repressed) of CHRM1 associated with repression
2) Confidence 0.27 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.29 Pain Relevance 0
Nicotine blocks the cholinergic receptor and thus blocks acetylcholine (ACh)-facilitated amino-acid transport.
Negative_regulation (blocks) of cholinergic receptor associated with nicotine
3) Confidence 0.22 Published 1991 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 1957023 Disease Relevance 0.25 Pain Relevance 0.72
DDT, TRPV3, PYCR1, AP2A2, ACBD6, SIRT7 and MRFAP1 were stimulated (Figure 2A and 2E–J, solid lines), and CHRM1 was repressed (Figure 2ZD).
Negative_regulation (repressed) of CHRM1
4) Confidence 0.20 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.15 Pain Relevance 0
The four genes most strongly repressed in C4-2B cells – MUC6, CHRM1, KIAA1217, and WBSCR28 – were also repressed in LNCaP cells, but repression generally occurred faster in the C4-2B cells (Figure 2ZC, ZD, ZE, ZF).
Negative_regulation (repressed) of CHRM1 associated with repression
5) Confidence 0.20 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.29 Pain Relevance 0
CHRM1 was also strongly repressed by androgens in vitro, yet it was found to be stimulated in vivo.
Negative_regulation (repressed) of CHRM1
6) Confidence 0.20 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.42 Pain Relevance 0
In these lobules, the effect of scorpion toxin was blocked by both atropine (an inhibitor of the cholinergic receptor on acinar cells) and tetrodotoxin (a selective blocker of Na+ channels in nerves).
Negative_regulation (inhibitor) of cholinergic receptor in acinar cells associated with tetrodotoxin
7) Confidence 0.06 Published 1981 Journal Gastroenterology Section Abstract Doc Link 6162711 Disease Relevance 0.07 Pain Relevance 0.23
Evidence that alpha 2-adrenergic pathways play a major role in growth hormone (GH) neuroregulation: alpha 2-adrenergic agonism counteracts the inhibitory effect of muscarinic cholinergic receptor blockade on the GH response to GH-releasing hormone, while alpha 2-adrenergic blockade diminishes the potentiating effect of increased cholinergic tone on such stimulation in normal men.
Negative_regulation (blockade) of cholinergic receptor
8) Confidence 0.04 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 1677361 Disease Relevance 0 Pain Relevance 0.28

General Comments

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