INT137301

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.49
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPH1) small molecule metabolic process (TPH1) cellular nitrogen compound metabolic process (TPH1)
response to stress (TPH1)
TPH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 19 100.00 Very High Very High Very High
5HT 6 100.00 Very High Very High Very High
fluoxetine 8 96.68 Very High Very High Very High
antagonist 5 93.64 High High
sSRI 3 90.64 High High
Migraine 8 88.40 High High
agonist 1 85.28 High High
Hippocampus 1 81.76 Quite High
Calcium channel 12 78.72 Quite High
Disease Link Frequency Relevance Heat
Headache 8 88.40 High High
Congenital Anomalies 4 85.36 High High
Convulsion 4 83.96 Quite High
Frailty 4 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR and immunostaining revealed the expression of serotonin transporter (SERT), 5HT(1A) receptors, tryptophan hydroxylase (TPH), and serotonin (5HT).
Negative_regulation (revealed) of Gene_expression (expression) of tryptophan hydroxylase associated with 5ht and serotonin
1) Confidence 0.12 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18573488 Disease Relevance 0 Pain Relevance 1.15
This decreased expression of tryptophan hydroxylase observed in both the daf-2 and unc-2 mutant backgrounds is suppressible either genetically by reduction-of-function mutations in the daf-16/forkhead transcription factor, an effector of the DAF-2/insulin receptor, or pharmacologically by the serotonin receptor antagonist cyproheptadine.
Negative_regulation (decreased) of Gene_expression (expression) of tryptophan hydroxylase associated with antagonist and serotonin
2) Confidence 0.03 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16860310 Disease Relevance 0.39 Pain Relevance 0.47
Here we show that developmental expression of a tryptophan hydroxylase: :GFP reporter construct is similarly decreased by reduction-of-function mutations in the daf-2/insulin receptor.
Negative_regulation (decreased) of Gene_expression (expression) of tryptophan hydroxylase
3) Confidence 0.02 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16860310 Disease Relevance 0.42 Pain Relevance 0.47
Overall, these data suggest that both UNC-2 and DAF-2 function are required in the developmental regulation of DAF-16 and serotonin-dependent inhibition of tryptophan hydroxylase expression.
Negative_regulation (inhibition) of Gene_expression (expression) of tryptophan hydroxylase associated with serotonin
4) Confidence 0.02 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16860310 Disease Relevance 0.29 Pain Relevance 0.40
This decreased expression of tryptophan hydroxylase observed in both the daf-2 and unc-2 mutant backgrounds is suppressible either genetically by reduction-of-function mutations in the daf-16/forkhead transcription factor, an effector of the DAF-2/insulin receptor, or pharmacologically by the serotonin receptor antagonist cyproheptadine.
Negative_regulation (suppressible) of Gene_expression (expression) of tryptophan hydroxylase associated with antagonist and serotonin
5) Confidence 0.02 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16860310 Disease Relevance 0.39 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox