INT13732

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1991
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.84
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH) extracellular region (GHRH) cell-cell signaling (GHRH)
Anatomy Link Frequency
pituitary 2
GHRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 14 99.98 Very High Very High Very High
Clonidine 5 93.52 High High
Somatostatin 5 62.88 Quite High
Opioid 2 50.00 Quite Low
Pain 2 46.16 Quite Low
narcan 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Fibromyalgia 13 99.98 Very High Very High Very High
Syndrome 2 54.32 Quite High
Fatigue 2 46.60 Quite Low
Pain 1 46.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Naloxone is able to decrease the effect of a maximal dose of GHRH, thus suggesting the existence of an opioid stimulatory tone on GH secretion.


Negative_regulation (decrease) of Regulation (effect) of GHRH
1) Confidence 0.43 Published 1998 Journal Horm. Metab. Res. Section Body Doc Link 9503036 Disease Relevance 0 Pain Relevance 0
Conversely, atropine pretreatment significantly (P less than 0.01) blocked the GH response to GHRH challenge, whereas yohimbine did not significantly affect it.
Negative_regulation (blocked) of Regulation (response) of GHRH
2) Confidence 0.41 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1677361 Disease Relevance 0 Pain Relevance 0.50
In conclusion, our data show that patients with FM exhibited a marked decrease in spontaneous GH secretion, but normal pituitary responsiveness to exogenously administered GHRH, thus suggesting the existence of an alteration at the hypothalamic level in the neuroendocrine control of GH in these patients.
Negative_regulation (exhibited) of Regulation (responsiveness) of GHRH in pituitary associated with fibrositis
3) Confidence 0.39 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10487713 Disease Relevance 0.84 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox