INT137350

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 4.14
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) cytoplasm (Src)
cell proliferation (Src) cell adhesion (Src) nucleus (Src)
Anatomy Link Frequency
SH2 1
Src (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 87 99.80 Very High Very High Very High
Morphine 160 99.44 Very High Very High Very High
nMDA receptor 4 98.88 Very High Very High Very High
opioid receptor 180 93.60 High High
substance P 2 86.16 High High
tolerance 56 83.56 Quite High
Analgesic 42 83.16 Quite High
nMDA receptor antagonist 1 82.60 Quite High
agonist 17 82.00 Quite High
metalloproteinase 1 79.92 Quite High
Disease Link Frequency Relevance Heat
Adhesions 22 99.56 Very High Very High Very High
Disorder Of Lipid Metabolism 1 99.26 Very High Very High Very High
Breast Cancer 195 98.44 Very High Very High Very High
Cancer 231 94.52 High High
Metastasis 142 92.36 High High
Noninfiltrating Intraductal Carcinoma 20 90.88 High High
Reprotox - General 1 51 84.60 Quite High
Osteoporosis 12 79.12 Quite High
Nociception 15 75.00 Quite High
Severe Combined Immunodeficiency 20 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 10 nmol morphine dose promoted PKC-mediated phosphorylation of NMDAR1 Ser890 and Src-mediated phosphorylation of NMDAR2A Tyr1325.
Phosphorylation (phosphorylation) of Src associated with kinase c and morphine
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.24
Implication of Src family kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in the rewarding effect of morphine.
Phosphorylation (phosphorylation) of Src associated with nmda receptor and morphine
2) Confidence 0.42 Published 2006 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Title Doc Link 16866212 Disease Relevance 0 Pain Relevance 0.63
The reeler gene encodes Reelin, a secreted glycoprotein that binds to the very-low-density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (Apoer 2), and induces Src- and Fyn-mediated tyrosine phosphorylation of the intracellular adaptor protein Disabled-1 (Dab1).
Phosphorylation (phosphorylation) of Src associated with disorder of lipid metabolism
3) Confidence 0.39 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279306 Disease Relevance 0.17 Pain Relevance 0.04
In particular, it has been shown that hydrogen peroxide, released as a consequence of LOX mediated catalysis, triggers the phosphorylation and activation of two key signal transduction pathway activators: Src and focal adhesion kinase (FAK).
Phosphorylation (phosphorylation) of Src associated with adhesions
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.91 Pain Relevance 0.04
The 10 nmol morphine dose promoted PKC-mediated phosphorylation of NMDAR1 Ser890 and Src-mediated phosphorylation of NMDAR2A Tyr1325.
Phosphorylation (phosphorylation) of Src associated with kinase c and morphine
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.22
However, the Src inhibitor, PP1 or the expression of a dominant-negative Src mutant, will reduce GPCR-mediated transphosphorylation of the EGFR and GPCR-mediated ERK activation to varying degrees (partial to total), suggesting that at least two different tyrosine kinases can be involved [18].
Phosphorylation (transphosphorylation) of Src
6) Confidence 0.28 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.11
This group of receptors signals through Src family kinase-dependent phosphorylation of the conserved tyrosines in the ITAM leading to recruitment of a Syk family kinase via its tandem SH2 domains, and stimulation of a downstream signaling cascade, which results in activation of phospholipase C (PLC) ?.
Phosphorylation (phosphorylation) of Src in SH2
7) Confidence 0.27 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
Tyr416 of Src is located in the kinase domain and phosphorylation of Src at this site enhances its catalytic activity.
Phosphorylation (phosphorylation) of Src
8) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 1.01 Pain Relevance 0
We observed a decrease in Src phosphorylation at Tyr416 in EGF-stimulated S100A7-downregulated cells as compared to the control cells (Figure 3C).
Phosphorylation (phosphorylation) of Src
9) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.18 Pain Relevance 0
In addition, reduced phosphorylation of Src at tyrosine 416 and p-SHP2 at tyrosine 542 was observed in these downregulated cell lines.
Phosphorylation (phosphorylation) of Src
10) Confidence 0.23 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2254193 Disease Relevance 0.52 Pain Relevance 0
We have seen decreased phosphorylation of c-Src at Tyr416 in S100A7-downregulated cell lines as compared to vector-transfected controls.
Phosphorylation (phosphorylation) of Src
11) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.80 Pain Relevance 0
ERK also appears to be involved in the phosphorylation of steroid receptor co-activator (SRC) -1, which binds to the androgen receptor [15].
Phosphorylation (phosphorylation) of SRC
12) Confidence 0.15 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.44 Pain Relevance 0.04
In the early events the translocated CagA protein undergoes tyrosine phophorylation by Src family kinases (see step 51).
Phosphorylation (phophorylation) of Src
13) Confidence 0.05 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0.06 Pain Relevance 0
In the later events tyrosine phophorylated CagA binds and activates CSK, which in turn phosphorylates and inactivates Src family kinases.
Phosphorylation (phosphorylates) of Src
14) Confidence 0.04 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0.05 Pain Relevance 0

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