INT137382

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 12.29
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT20) cytoplasm (KRT20)
Anatomy Link Frequency
blood 4
macrophages 2
plasma 2
bone marrow 2
B-cell 2
KRT20 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 83 100.00 Very High Very High Very High
tetrodotoxin 23 99.68 Very High Very High Very High
potassium channel 29 93.84 High High
Nav1.7 13 91.44 High High
Glutamate 4 84.80 Quite High
Cauda equina syndrome 1 83.08 Quite High
Glutamate receptor 2 80.80 Quite High
nMDA receptor 1 77.52 Quite High
imagery 20 66.56 Quite High
Inflammation 50 58.76 Quite High
Disease Link Frequency Relevance Heat
Endometrial Cancer 153 99.68 Very High Very High Very High
Adenocarcinoma 200 99.52 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 20 99.52 Very High Very High Very High
Epstein-barr Virus 30 98.92 Very High Very High Very High
Disorder Of Lipid Metabolism 1 98.88 Very High Very High Very High
Diffuse Large B-cell Lymphoma 56 98.64 Very High Very High Very High
Colorectal Cancer 20 98.40 Very High Very High Very High
Systemic Lupus Erythematosus 252 97.68 Very High Very High Very High
Cancer 478 96.92 Very High Very High Very High
Microsatellite Instability 51 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DIAGNOSIS: Chemoresistant diffuse large B-cell lymphoma, with gradual loss of CD20 antigen expression.
Negative_regulation (loss) of Gene_expression (expression) of CD20 in B-cell
1) Confidence 0.58 Published 2008 Journal Nature clinical practice. Oncology Section Body Doc Link 18797436 Disease Relevance 0.43 Pain Relevance 0
However, CD20 expression was decreased remarkably compared with that in the CSF and that in the bone marrow before therapy.
Negative_regulation (decreased) of Gene_expression (expression) of CD20 in bone marrow
2) Confidence 0.41 Published 2006 Journal Int. J. Hematol. Section Abstract Doc Link 16867907 Disease Relevance 0.87 Pain Relevance 0.08
Classically, adenocarcinoma of the lung, breast ovary and omentum are CK7 positive and CK20 negative, while adenocarcinoma of colorectal origin tends to have the opposite (CK7 negative and CK20 positive) [4,15].
Negative_regulation (opposite) of Neg (negative) Gene_expression (negative) of CK20 in ovary associated with adenocarcinoma
3) Confidence 0.41 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2092434 Disease Relevance 0.86 Pain Relevance 0
In a large tissue microarray study, reduced expression of K8 and K20 was found to be associated with shorter patients’ survival, possibly on the basis of epithelial-mesenchymal transition (Knösel et al. 2006).
Negative_regulation (reduced) of Gene_expression (expression) of K20
4) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.80 Pain Relevance 0
Keratin K13 is also expressed in the urothelium as a major component of the basal and intermediate cells whereas it is lost in the superficial umbrella cells (that switch on K20 expression; see above).
Negative_regulation (switch) of Gene_expression (expression) of K20
5) Confidence 0.25 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.06 Pain Relevance 0
Thus, reduced expression of K20 has been found in a specific subset of colorectal carcinomas with high levels of microsatellite instability (McGregor et al. 2004); notably, K7 expression remained low in these tumors.
Negative_regulation (reduced) of Gene_expression (expression) of K20 associated with colorectal cancer, cancer and microsatellite instability
6) Confidence 0.25 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.93 Pain Relevance 0
Adenocarcinomas of the stomach usually show heterogeneous expression of both K7 and K20, the latter being rather variable but yet expressed in the majority of cases (Moll 1998, Chu and Weiss 2002b).
Negative_regulation (show) of Gene_expression (expression) of K20 in stomach associated with adenocarcinoma
7) Confidence 0.25 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.85 Pain Relevance 0
Analysis of PCs in blood from this patient several months later showed a normal number of CD27++/CD20?
Negative_regulation (number) of Gene_expression (/) of CD20 in blood
8) Confidence 0.13 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.84 Pain Relevance 0
The absolute number of CD27++/CD20?
Negative_regulation (number) of Gene_expression (/) of CD20
9) Confidence 0.13 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.73 Pain Relevance 0
No differences in absolute numbers of CD27++/CD20?
Negative_regulation (numbers) of Gene_expression (/) of CD20
10) Confidence 0.13 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.50 Pain Relevance 0
The absolute number of CD27++/CD20?
Negative_regulation (number) of Gene_expression (/) of CD20
11) Confidence 0.13 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.45 Pain Relevance 0
In specific experiments, the expression of CD19 and CD20 disappeared almost completely after rotation at 16 to 20 rpm, while slower rotation (8 rpm) could partially prevent this effect (Figure 3a).
Negative_regulation (disappeared) of Gene_expression (expression) of CD20
12) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.14 Pain Relevance 0
Reduced VEGF protein expression in primary HIV-1-positive BL and DLBCL, compared to the negative cases, supported the findings of promoter downregulation from the cell lines.
Negative_regulation (Reduced) of Gene_expression (expression) of protein associated with acquired immune deficiency syndrome or hiv infection, epstein-barr virus and diffuse large b-cell lymphoma
13) Confidence 0.08 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.40 Pain Relevance 0
Identity of the cell infiltrates was determined with a combination of haematoxylin staining and immunohistochemistry staining for CD68 (macrophages), CD3 (T cells), CD56 (NK cells) and CD20 (B cell) after antigen retrieval using microwave and citrate or EDTA buffer methods [14].
Spec (determined) Negative_regulation (combination) of Gene_expression (macrophages) of CD20 in macrophages
14) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2872666 Disease Relevance 0.36 Pain Relevance 0.03
Results indicate that HCEC from older donors exhibit reduced expression of proteins that support important cellular functions such as metabolism, antioxidant protection, protein folding, and protein degradation.
Negative_regulation (reduced) of Gene_expression (expression) of protein
15) Confidence 0.03 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2565687 Disease Relevance 0 Pain Relevance 0
The decreased expression of both message and protein in preterm tissues however (Fig. 3C, 4B) is consistent with our hypothesis.
Negative_regulation (decreased) of Gene_expression (expression) of protein
16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0 Pain Relevance 0.11
Thus, application of TTX (500 nM) alone reduced total and plasma membrane VGSC protein expressions by 12 ± 1.5 % and 10 ± 1.4 %, respectively (p < 0.01 for both; n = 5–6; Fig. 6).
Negative_regulation (reduced) of Gene_expression (expressions) of VGSC protein in plasma associated with tetrodotoxin and sodium channel
17) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.18 Pain Relevance 0.88
4 genotype (APOE) [96], decreased expression of EAAT2 protein [97,98] and alterations in the Vascular endothelial growth factor (VEGF) gene [99] to name a few (See Table 2).

2.

Negative_regulation (decreased) of Gene_expression (expression) of protein
18) Confidence 0.00 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 0.80 Pain Relevance 0.19
Loss of protein expression seems to occur frequently for both MLH1 and MSH2 in endometrial hyperplasia and is considered an early event during tumor development [11].
Negative_regulation (Loss) of Gene_expression (expression) of protein in MLH1 associated with cancer and endometrial cancer
19) Confidence 0.00 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 2.06 Pain Relevance 0
These results occur despite absolute concentrations of amino acids, meaning that a decrease in protein synthesis will occur even when amino acid concentrations remain elevated above basal levels.
Negative_regulation (decrease) of Gene_expression (synthesis) of protein
20) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0.05 Pain Relevance 0

General Comments

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