INT13739

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Context Info
Confidence 0.70
First Reported 1983
Last Reported 2009
Negated 1
Speculated 3
Reported most in Abstract
Documents 18
Total Number 22
Disease Relevance 4.78
Pain Relevance 8.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
plasma 18
neurons 5
hypothalamus 4
nucleus 4
CVLM 2
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 9 100.00 Very High Very High Very High
medulla 6 99.98 Very High Very High Very High
Pain 18 99.74 Very High Very High Very High
narcan 16 99.72 Very High Very High Very High
Paracetamol 6 99.72 Very High Very High Very High
agonist 7 99.66 Very High Very High Very High
fluoxetine 4 99.56 Very High Very High Very High
Raphe magnus 16 99.36 Very High Very High Very High
Nicotine 4 99.24 Very High Very High Very High
noradrenaline 5 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 12 99.80 Very High Very High Very High
Pain 16 99.74 Very High Very High Very High
Body Weight 1 99.04 Very High Very High Very High
Myocardial Infarction 26 98.92 Very High Very High Very High
Hemorrhage 4 97.32 Very High Very High Very High
Hypertension 5 85.28 High High
Diuresis 1 84.00 Quite High
Hypotension 1 78.56 Quite High
Renal Disease 4 75.00 Quite High
Natriuresis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that pain stimulation increased the AVP concentration in the NRM perfusion liquid, PVN cauterization inhibited the role that pain stimulation induced the increase of AVP concentration in the NRM perfusion liquid, and PVN microinjection of L-glutamate sodium, which excited the PVN neurons, could increase the AVP concentration in the NRM perfusion liquid.
Positive_regulation (induced) of Positive_regulation (increase) of AVP in neurons associated with raphe magnus, pain and glutamate
1) Confidence 0.70 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.61 Pain Relevance 1.09
Results indicate that TOT deafferentations resulted in significant increases in CRH mRNA expression in the PVN, and a slight but noticeable induction of AVP mRNA in the medial parvocellular but not posterior magnocellular divisions of the PVN.
Positive_regulation (resulted) of Positive_regulation (induction) of AVP in PVN
2) Confidence 0.68 Published 1990 Journal Endocrinology Section Abstract Doc Link 2171915 Disease Relevance 0 Pain Relevance 0
Our previous study has pointed that pain stimulation induced AVP increase in the nucleus raphe magnus (NRM), which plays a role in pain modulation.
Positive_regulation (induced) of Positive_regulation (increase) of AVP in nucleus associated with raphe magnus and pain
3) Confidence 0.50 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.60 Pain Relevance 0.91
Tyramine injections also resulted in a prompt elevation in plasma vasopressin, indicating that endogenous noradrenaline is capable of releasing vasopressin.
Positive_regulation (resulted) of Positive_regulation (elevation) of vasopressin in plasma associated with noradrenaline
4) Confidence 0.50 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3031526 Disease Relevance 0 Pain Relevance 0.30
The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus.
Positive_regulation (colchicine-induced) of Positive_regulation (accumulation) of AVP in hypothalamus associated with neuropeptide
5) Confidence 0.50 Published 1991 Journal Life Sci. Section Abstract Doc Link 1677440 Disease Relevance 0 Pain Relevance 0.22
The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus.
Positive_regulation (colchicine-induced) of Positive_regulation (accumulation) of vasopressin in hypothalamus associated with neuropeptide
6) Confidence 0.50 Published 1991 Journal Life Sci. Section Abstract Doc Link 1677440 Disease Relevance 0 Pain Relevance 0.22
Addition of 1 x 10-7 M NMDA or 1 x 10-6 M kainate to the incubation medium antagonized the salt loading-induced increase in vasopressin release.
Positive_regulation (loading-induced) of Positive_regulation (increase) of vasopressin
7) Confidence 0.50 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 11012837 Disease Relevance 0 Pain Relevance 0.47
These results suggest an inhibitory role for local NO in the CVLM and that nitrergic pathways at the CVLM participate in the central regulation of AVP release.
Neg (NO) Positive_regulation (participate) of Positive_regulation (regulation) of AVP in CVLM associated with medulla
8) Confidence 0.47 Published 1999 Journal Neuroreport Section Abstract Doc Link 10208539 Disease Relevance 0.15 Pain Relevance 0.30
A microradioimmunoassay for cAMP was developed in order to analyse the effects of alpha-adrenergic agonists on vasopressin (AVP)-induced cAMP cell accumulation in single pieces of microdissected medullary (MCT) and cortical (CCT) rat collecting tubules.
Spec (analyse) Positive_regulation (induced) of Spec (analyse) Positive_regulation (accumulation) of AVP in collecting tubules associated with agonist
9) Confidence 0.47 Published 1984 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 6149967 Disease Relevance 0 Pain Relevance 0.09
ANF III had no effect on the basal plasma AVP and OXT concentrations, however, the peptide inhibited the plasma AVP and OXT elevation induced by hyperosmosis (intraperitoneal injection of 2.5% NaCl).
Positive_regulation (induced) of Positive_regulation (elevation) of plasma AVP in plasma
10) Confidence 0.46 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2978124 Disease Relevance 0.15 Pain Relevance 0.17
Chloroquine administration in paracetamol treated rats induced a significant reduction (p < 0.05) in urine flow rate and a significant increase in plasma vasopressin (p < 0.001).
Positive_regulation (induced) of Positive_regulation (increase) of vasopressin in plasma associated with paracetamol
11) Confidence 0.42 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649360 Disease Relevance 0.40 Pain Relevance 0.83
Naloxone pretreatment caused augmented AVP and OT secretion in response to hypertonic saline stimulation and hemorrhage in both the normonatremic and hyponatremic rats; the magnitude of the naloxone augmentations in the hyponatremic rats were sufficient to normalize the OT response to hypertonic saline and both the OT and AVP responses to hemorrhage.
Positive_regulation (caused) of Positive_regulation (augmented) of AVP associated with narcan and cva
12) Confidence 0.41 Published 1995 Journal J. Neuroendocrinol. Section Abstract Doc Link 7735298 Disease Relevance 0.28 Pain Relevance 0.43
Adrenalectomy-induced enhancement of CRF and vasopressin immunoreactivity in parvocellular neurosecretory neurons: anatomic, peptide, and steroid specificity.
Positive_regulation (Adrenalectomy-induced) of Positive_regulation (enhancement) of vasopressin in neurosecretory neurons associated with neuropeptide
13) Confidence 0.40 Published 1987 Journal J. Neurosci. Section Title Doc Link 3553442 Disease Relevance 0 Pain Relevance 0.21
A significant (P < 0.05) short term increase in both plasma vasopressin and oxytocin occurred 1 min after injection of 5 micrograms relaxin, iv, in angiotensin-II-antagonized rats, but the concentrations of both neuropeptides were significantly (P < 0.05) lower than those observed in the angiotensin-intact relaxin-treated controls.
Positive_regulation (occurred) of Positive_regulation (increase) of vasopressin in plasma associated with neuropeptide
14) Confidence 0.38 Published 1994 Journal Endocrinology Section Abstract Doc Link 8119158 Disease Relevance 0 Pain Relevance 0.09
In urethane-anaesthetized ovariectomized rats, injection of porcine relaxin (7.5 and 15 micrograms/kg, i.v.) caused a sustained increase in circulating plasma oxytocin and vasopressin concentrations; 10 micrograms relaxin/rat i.v. produced a smaller but significant increase in plasma oxytocin concentration in conscious ovariectomized rats.
Positive_regulation (caused) of Positive_regulation (increase) of vasopressin in plasma
15) Confidence 0.34 Published 1992 Journal J. Endocrinol. Section Abstract Doc Link 1737954 Disease Relevance 0 Pain Relevance 0
The concentrations of oxytocin and vasopressin in plasma were elevated (p less than 0.05) by histamine, isoproterenol (30 and 120 micrograms/kg), increases[NaCl] in CSF, and nicotine at the higher (1.5 mg/kg) but not lower (0.15 mg/kg) dose.
Positive_regulation (increases) of Positive_regulation (elevated) of vasopressin in plasma associated with nicotine
16) Confidence 0.25 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3796791 Disease Relevance 0.11 Pain Relevance 0.65
Compared with responses in WKY, SHR showed an increased ACTH response to high doses of vasopressin (0.25 micrograms/100 g body weight) at both ages (p less than 0.05).
Positive_regulation (increased) of Positive_regulation (response) of vasopressin in body associated with body weight
17) Confidence 0.18 Published 1986 Journal Hypertension Section Abstract Doc Link 3009324 Disease Relevance 0.32 Pain Relevance 0.16
Fluoxetine caused a significant increase in ACTH and AVP concentrations in peripheral plasma as well as a significant increase in CRF and AVP concentrations in hypophysial portal plasma.
Positive_regulation (increase) of Positive_regulation (increase) of AVP in plasma associated with fluoxetine
18) Confidence 0.17 Published 1983 Journal Brain Res. Section Abstract Doc Link 6317143 Disease Relevance 0 Pain Relevance 0.50
The opiate antagonist naloxone given both centrally and systemically attenuated the increase in plasma concentration of AVP induced by FK-33824.
Positive_regulation (increase) of Positive_regulation (induced) of AVP in plasma associated with antagonist, narcan and opiate
19) Confidence 0.15 Published 1989 Journal Acta Endocrinol. Section Abstract Doc Link 2929239 Disease Relevance 0 Pain Relevance 1.16
These data support the conclusion that vasopressin producing neurons and autonomic areas within the hypothalamus influenced by vagal afferents are activated during HF and are sensitive to 'acute surgical stress' and may contribute to the elevated levels of vasopressin and sympatho-excitation commonly observed in heart failure.
Spec (may) Positive_regulation (contribute) of Positive_regulation (elevated) of vasopressin in neurons associated with stress and myocardial infarction
20) Confidence 0.13 Published 2000 Journal Brain Res. Section Abstract Doc Link 10814730 Disease Relevance 0.91 Pain Relevance 0.05

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