INT13741

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Context Info
Confidence 0.56
First Reported 1984
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 0.44
Pain Relevance 4.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
plasma 6
hypothalamus 6
supraoptic nucleus 4
uterus 2
brainstem 2
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 9 99.92 Very High Very High Very High
Endogenous opioid 6 99.82 Very High Very High Very High
narcan 23 99.76 Very High Very High Very High
antagonist 5 99.58 Very High Very High Very High
opiate 3 99.36 Very High Very High Very High
bradykinin 2 98.76 Very High Very High Very High
fluoxetine 11 98.60 Very High Very High Very High
agonist 4 98.60 Very High Very High Very High
medulla 3 97.64 Very High Very High Very High
Enkephalin 3 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 2 96.32 Very High Very High Very High
Natriuresis 2 75.00 Quite High
Reprotox - General 3 1 63.28 Quite High
Dysmenorrhea 2 62.32 Quite High
Diabetes Mellitus 4 25.00 Low Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Breast Cancer 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant (P < 0.05) short term increase in both plasma vasopressin and oxytocin occurred 1 min after injection of 5 micrograms relaxin, iv, in angiotensin-II-antagonized rats, but the concentrations of both neuropeptides were significantly (P < 0.05) lower than those observed in the angiotensin-intact relaxin-treated controls.
Positive_regulation (occurred) of Positive_regulation (increase) of oxytocin in plasma associated with neuropeptide
1) Confidence 0.56 Published 1994 Journal Endocrinology Section Abstract Doc Link 8119158 Disease Relevance 0 Pain Relevance 0.09
All modes of stimulation induced significant elevations of oxytocin levels in plasma and/or in CSF, 30 or 90 min after the end of stimulation.
Positive_regulation (induced) of Positive_regulation (elevations) of oxytocin in plasma
2) Confidence 0.51 Published 1993 Journal Acta Physiol. Scand. Section Abstract Doc Link 8266809 Disease Relevance 0 Pain Relevance 0.35
The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus.
Positive_regulation (colchicine-induced) of Positive_regulation (accumulation) of OXT in hypothalamus associated with neuropeptide
3) Confidence 0.49 Published 1991 Journal Life Sci. Section Abstract Doc Link 1677440 Disease Relevance 0 Pain Relevance 0.23
The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus.
Positive_regulation (colchicine-induced) of Positive_regulation (accumulation) of oxytocin in hypothalamus associated with neuropeptide
4) Confidence 0.49 Published 1991 Journal Life Sci. Section Abstract Doc Link 1677440 Disease Relevance 0 Pain Relevance 0.22
This injection resulted in significantly elevated plasma oxytocin levels and increased discharge activity of putative oxytocin cells in the supraoptic nucleus.
Positive_regulation (resulted) of Positive_regulation (increased) of oxytocin in supraoptic nucleus
5) Confidence 0.47 Published 1988 Journal Neurosci. Lett. Section Abstract Doc Link 3399134 Disease Relevance 0 Pain Relevance 0.16
This injection resulted in significantly elevated plasma oxytocin levels and increased discharge activity of putative oxytocin cells in the supraoptic nucleus.
Positive_regulation (resulted) of Positive_regulation (elevated) of oxytocin in supraoptic nucleus
6) Confidence 0.47 Published 1988 Journal Neurosci. Lett. Section Abstract Doc Link 3399134 Disease Relevance 0 Pain Relevance 0.15
In pregnancy, endogenous opioids inhibit enhanced basal and stressor-stimulated oxytocin neurone activity and secretion.
Positive_regulation (stressor-stimulated) of Positive_regulation (enhanced) of oxytocin associated with endogenous opioid
7) Confidence 0.45 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10718931 Disease Relevance 0.17 Pain Relevance 0.21
ANF III had no effect on the basal plasma AVP and OXT concentrations, however, the peptide inhibited the plasma AVP and OXT elevation induced by hyperosmosis (intraperitoneal injection of 2.5% NaCl).
Positive_regulation (induced) of Positive_regulation (induced) of OXT in plasma
8) Confidence 0.44 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2978124 Disease Relevance 0.15 Pain Relevance 0.17
We investigated whether a sustained increase in oxytocin secretion, with or without enhanced electrical activity of the cell-bodies of oxytocin neurones, leads to a rapid increase in oxytocin mRNA content in these neurones.
Spec (whether) Positive_regulation (leads) of Spec (whether) Positive_regulation (increase) of oxytocin
9) Confidence 0.43 Published 1989 Journal Brain Res. Section Abstract Doc Link 2743158 Disease Relevance 0 Pain Relevance 0.27
The lipophilic sub-fraction, instead, induced a dose-dependent inhibitory activity on the in vitro response to oxytocin, prostaglandin F(2alpha,) and bradykinin of uterine horns from naïve 28-day-old rats, with a potency rate close to 1:30 of that of 17 beta-estradiol.
Positive_regulation (induced) of Positive_regulation (response) of oxytocin in uterine horns associated with bradykinin and potency
10) Confidence 0.43 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17689956 Disease Relevance 0.13 Pain Relevance 0.28
The opiate antagonist naloxone (10(-5) M) induced an increase in the evoked VP and, even more pronounced, OT release.
Positive_regulation (induced) of Positive_regulation (increase) of OT associated with antagonist, narcan and opiate
11) Confidence 0.39 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6152015 Disease Relevance 0 Pain Relevance 1.14
Because hypothalamic Gz proteins mediate the ACTH and oxytocin responses to 5-HT1A receptor activation, we also determined the effect of fluoxetine on the levels of Gz proteins in the hypothalamus.
Positive_regulation (mediate) of Positive_regulation (activation) of oxytocin in hypothalamus associated with fluoxetine
12) Confidence 0.11 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9862759 Disease Relevance 0 Pain Relevance 0.65
An increase in oxytocin was observed in the uterus of rats as expected when treated with a single of OP (13.6-fold), NP (17.4-fold) and BPA (1.5-fold) for 3 days Furthermore, treatment with a single dose of E2 (9.9-fold) or DES (30.5-fold) resulted in an increase of oxytocin in this tissue.
Positive_regulation (resulted) of Positive_regulation (increase) of oxytocin in uterus
13) Confidence 0.10 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
Central administration of neuropeptide FF causes activation of oxytocin paraventricular hypothalamic neurones that project to the brainstem.
Positive_regulation (causes) of Positive_regulation (activation) of oxytocin in brainstem associated with medulla and neuropeptide
14) Confidence 0.09 Published 2003 Journal J. Neuroendocrinol. Section Title Doc Link 12535166 Disease Relevance 0 Pain Relevance 0.37

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