INT137412

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 4.03
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cast) cell cycle (Cast) cytoplasm (Cast)
Anatomy Link Frequency
hepatocytes 1
paw 1
neurons 1
astrocytes 1
cortex 1
Cast (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 8 95.52 Very High Very High Very High
Paracetamol 4 80.80 Quite High
Spinal cord 4 79.28 Quite High
Eae 88 66.32 Quite High
Hippocampus 48 55.84 Quite High
Abeta 4 50.00 Quite Low
long-term potentiation 56 48.68 Quite Low
amygdala 12 43.64 Quite Low
nMDA receptor 8 33.32 Quite Low
Glutamate receptor 12 30.12 Quite Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 60 98.28 Very High Very High Very High
Urological Neuroanatomy 12 98.24 Very High Very High Very High
Congenital Anomalies 12 96.68 Very High Very High Very High
Injury 16 96.36 Very High Very High Very High
Pain 4 95.52 Very High Very High Very High
Targeted Disruption 296 91.00 High High
Hepatotoxicity 3 90.16 High High
Post-traumatic Stress Disorder 20 85.04 High High
Neuroblastoma 4 83.24 Quite High
Disease 40 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calpastatin (CS) is the endogenous inhibitor of intracellular cysteine protease calpain.
Negative_regulation (inhibitor) of Calpastatin
1) Confidence 0.49 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 0.10 Pain Relevance 0
In all three models, CAST was upregulated in the dividing/newly divided hepatocytes and declined to normal levels with the cessation of cell proliferation.
Negative_regulation (declined) of CAST in hepatocytes
2) Confidence 0.38 Published 2006 Journal Hepatology Section Abstract Doc Link 16871587 Disease Relevance 0.95 Pain Relevance 0.30
Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease.
Negative_regulation (inhibitor) of Calpastatin
3) Confidence 0.36 Published 2008 Journal Mol Brain Section Abstract Doc Link PMC2561015 Disease Relevance 0.28 Pain Relevance 0.06
Takano et al. [5] demonstrated that calpastatin is a negative regulator of calpain under pathological conditions, implying that CS may not be fully responsible for inhibition of calpain activation and action under the normal conditions.
Negative_regulation (regulator) of calpastatin
4) Confidence 0.36 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 0.99 Pain Relevance 0.07
In the hot plate test, latency to the first paw response was not affected by the lack of calpastatin (F1,36 = 1.93, P = 0.174).
Negative_regulation (lack) of calpastatin in paw
5) Confidence 0.31 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 0.82 Pain Relevance 0.10
(25–25)-induced calpain increase and calpastatin decrease occurred also in GFAP-positive astrocytes, and those were inhibited by Kihi-to-treatment (data not shown).
Negative_regulation (decrease) of calpastatin in astrocytes
6) Confidence 0.27 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.66 Pain Relevance 0
For measuring levels of calpain and calpastatin, the cells were incubated with 10 ?
Negative_regulation (levels) of calpastatin
7) Confidence 0.26 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0 Pain Relevance 0
By contrast, the expression level of calpastatin, an endogenous inhibitor of calpain, in the cytosol of MAP2-positive neurons continuously decreased at 2 h to 96 h after the treatment of A?
Negative_regulation (level) of calpastatin in neurons
8) Confidence 0.26 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.13 Pain Relevance 0
On the other hand, expression levels of calpastatin tended to be decreased in the cortex and CA3 of A?
Negative_regulation (levels) of calpastatin in cortex
9) Confidence 0.26 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.10 Pain Relevance 0

General Comments

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