INT137418

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.63 Pain Relevance 0.28

signal transduction (MAPK7, TNF) cell differentiation (MAPK7) nucleoplasm (MAPK7) intracellular (TNF) extracellular matrix organization (TNF) cytoplasm (MAPK7)

MAPK7 (Homo sapiens) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 5 92.16 Acupuncture 1 70.48 Osteoarthritis 1 64.20 Analgesic 1 59.00 Inflammation 1 58.44

Disease Link Frequency Relevance Heat Cancer 1 100.00 Necrosis 1 100.00 Osteoporosis 5 86.92 Osteoarthritis 1 64.20 INFLAMMATION 1 58.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On the other hand, BMK strongly inhibited interleukin-1beta (IL-1beta)- and tumor necrosis factor (TNF)alpha-induced Nitricoxide (NO) synthase expression with little effect on constitutive NO synthase expression.

BMK Negative_regulation (inhibited) of Gene_expression (expression) of TNF associated with necrosis and cancer

1) Confidence 0.01 Published 2006 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 16873093 Disease Relevance 0.63 Pain Relevance 0.28

General Comments

This test has worked.