INT137420

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.22
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MAPK7) cytosol (MAPK7) nucleoplasm (MAPK7)
signal transduction (MAPK7) nucleus (MAPK7) cell cycle (MAPK7)
Anatomy Link Frequency
Caco-2 1
TEK 1
MAPK7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 7 98.60 Very High Very High Very High
metalloproteinase 6 93.80 High High
member 8 1 91.04 High High
Acupuncture 1 59.48 Quite High
Osteoarthritis 1 53.20 Quite High
Analgesic 1 48.00 Quite Low
Inflammation 7 47.44 Quite Low
aspirin 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 132 99.12 Very High Very High Very High
Rheumatoid Arthritis 38 98.68 Very High Very High Very High
Necrosis 2 91.84 High High
Cancer 67 91.48 High High
Osteoporosis 5 75.92 Quite High
Neurodegenerative Disease 8 75.12 Quite High
Ductal Carcinoma 1 56.92 Quite High
Malignant Neoplastic Disease 2 53.92 Quite High
Osteoarthritis 1 53.20 Quite High
Breast Cancer 23 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RA is known to activate ERK5 (MAPK7), suggesting that the increased expression of ERK5 (MAPK7) in CD34+ cells from CAD patients may be related to an increased sensitivity to RA [26].
Gene_expression (expression) of ERK5 associated with coronary artery disease and rheumatoid arthritis
1) Confidence 0.59 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 1.03 Pain Relevance 0
RA is known to activate ERK5 (MAPK7), suggesting that the increased expression of ERK5 (MAPK7) in CD34+ cells from CAD patients may be related to an increased sensitivity to RA [26].
Gene_expression (expression) of MAPK7 associated with coronary artery disease and rheumatoid arthritis
2) Confidence 0.59 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 1.03 Pain Relevance 0
ERK5-mediated phosphorylation of the transcription factor Ets-1 enhanced 1,25(OH)(2)D(3)-mediated CYP24 gene transcription in proliferating but not differentiated Caco-2 cells due to reduced levels of ERK5 and Ets-1 (total and phosphoprotein levels) in differentiated cells.
Gene_expression (levels) of ERK5 in Caco-2
3) Confidence 0.50 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19097033 Disease Relevance 0 Pain Relevance 0.09
On the other hand, right branch shows overexpression areas with genes such as CASP 10, CD30-L, and CD-40-L (TNF family), ras-like small, FGF 3 and 5, TDGF1, ERK5, MIF, IFNGR2, MIG, IFN-alpha, beta, gamma, IL-3, -4, -9 and -13, IP-10, HPRT, DCC, TEK, netrin-2, cadherins 4, 8, 12 and 13 [33], MMP3, 8, 10, 12 and 13 (metalloproteinase), COL11A2, CCNG1, CDC-6, ATM, N-MYC, and p53.
Gene_expression (overexpression) of ERK5 in TEK associated with metalloproteinase
4) Confidence 0.49 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.66 Pain Relevance 0.05
BMK (10 microg/ml) did not affect the ecNOS expression, indicating the extracts are not working on the constitutive NOS expression.
Gene_expression (expression) of BMK
5) Confidence 0.04 Published 2006 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 16873093 Disease Relevance 0.50 Pain Relevance 0.19

General Comments

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