INT13743

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 4
Speculated 5
Reported most in Abstract
Documents 30
Total Number 35
Disease Relevance 6.90
Pain Relevance 11.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
PVN 16
pituitary 6
hypothalamus 4
cerebellum 3
plasma 2
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Acupuncture 26 100.00 Very High Very High Very High
Morphine 22 100.00 Very High Very High Very High
Dynorphin 17 100.00 Very High Very High Very High
narcan 7 100.00 Very High Very High Very High
withdrawal 5 100.00 Very High Very High Very High
methadone 5 100.00 Very High Very High Very High
Neurotransmitter 3 99.98 Very High Very High Very High
analgesia 14 99.76 Very High Very High Very High
Enkephalin 8 99.48 Very High Very High Very High
Raphe magnus 1 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hemorrhagic Shock 8 100.00 Very High Very High Very High
Diabetes Mellitus 4 99.84 Very High Very High Very High
Nociception 10 99.74 Very High Very High Very High
Stress 11 99.36 Very High Very High Very High
Natriuresis 9 99.04 Very High Very High Very High
Cystitis 4 98.68 Very High Very High Very High
Urological Neuroanatomy 3 98.62 Very High Very High Very High
Hyponatremia 3 98.36 Very High Very High Very High
Chronic Renal Failure 248 97.56 Very High Very High Very High
Depression 35 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Forskolin-induced AVP hnRNA expression was unaffected by blockage of neurotransmission by the sodium channel inhibitor, tetrodotoxin, indicating that forskolin acts directly on AVP cells in the PVN.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of AVP hnRNA in PVN associated with tetrodotoxin and sodium channel
1) Confidence 0.62 Published 2001 Journal Endocrinology Section Abstract Doc Link 11606471 Disease Relevance 0 Pain Relevance 0.15
In the present study, we examined how cAMP and glucocorticoids regulate AVP gene expression in the parvocellular neurons of the PVN in rat hypothalamic organotypic cultures with in situ hybridization.
Spec (examined) Regulation (regulate) of Gene_expression (expression) of AVP gene in PVN
2) Confidence 0.62 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.03
Regulation of vasopressin gene expression by cAMP and glucocorticoids in parvocellular neurons of the paraventricular nucleus in rat hypothalamic organotypic cultures.
Regulation (Regulation) of Gene_expression (expression) of vasopressin gene in neurons
3) Confidence 0.62 Published 2003 Journal J. Neurosci. Section Title Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.25
Thus, the syntheses of immunoreactive dynorphin and vasopressin in the hypothalamo-hypophyseal tract appear to be independently regulated.
Regulation (regulated) of Gene_expression (syntheses) of vasopressin associated with dynorphin
4) Confidence 0.59 Published 1980 Journal Neurosci. Lett. Section Abstract Doc Link 6133255 Disease Relevance 0 Pain Relevance 0.30
Together, our results demonstrate robust and rapid changes in the expression of the AVP-eGFP transgene in the rat hypothalamus after acute nociceptive stimulation.
Regulation (changes) of Gene_expression (expression) of AVP-eGFP transgene in hypothalamus associated with nociception
5) Confidence 0.48 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19846706 Disease Relevance 0.23 Pain Relevance 0
Electrical acupuncture of "Zusanli" points (St. 36) decreased AVP concentration in the hypothalamic paraventricular nucleus (PVN), and increased AVP concentration in the hypothalamic supraoptic nucleus (SON), periaqueductial gray (PAG), caudate nucleus (CdN) and raphe magnus nucleus (RMN), but did not change AVP concentration in the pituitary, spinal cord and plasma.
Neg (not) Regulation (change) of Gene_expression (concentration) of AVP in raphe magnus nucleus associated with raphe magnus, urological neuroanatomy, acupuncture and spinal cord
6) Confidence 0.45 Published 2009 Journal Peptides Section Abstract Doc Link 19022309 Disease Relevance 0.17 Pain Relevance 1.37
No or insignificant preprovasopressin mRNA expression was present in the cerebellum, locus coeruleus, subcoeruleus, or the spinal cord.
Regulation (present) of Gene_expression (expression) of preprovasopressin mRNA in cerebellum associated with locus ceruleus and spinal cord
7) Confidence 0.45 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10404247 Disease Relevance 0.09 Pain Relevance 0.30
Lipopolysaccharide endotoxin potentiates the effect of osmotic stimulation on vasopressin synthesis and secretion in the rat hypothalamus.
Regulation (effect) of Gene_expression (synthesis) of vasopressin in hypothalamus
8) Confidence 0.45 Published 2003 Journal J. Neuroendocrinol. Section Title Doc Link 12535156 Disease Relevance 0.07 Pain Relevance 0.05
Effect of naloxone-precipitated morphine withdrawal on CRH and vasopressin mRNA expression in the rat hypothalamic paraventricular nucleus.
Regulation (Effect) of Gene_expression (expression) of vasopressin in nucleus associated with narcan, withdrawal and morphine
9) Confidence 0.44 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12431775 Disease Relevance 0.21 Pain Relevance 1.32
The limited up-regulation (compared with adrenalectomized rats) of AVP mRNA in the TOT group suggests that while neuronal input may have some control of AVP mRNA expression, local glucocorticoid feedback is clearly able to restrict AVP message to levels considerably less than those seen in steroid-deficient animals.
Regulation (control) of Gene_expression (expression) of AVP in neuronal
10) Confidence 0.44 Published 1990 Journal Endocrinology Section Abstract Doc Link 2171915 Disease Relevance 0 Pain Relevance 0.10
The effect of acupuncture on the concentrations of arginine vasopressin (AVP), oxytocin (OXT), leucine-enkephaline (L-Ek), beta-endorphin (beta-Ep) and dynorphinA(1-13) (DynA(1-13)) was investigated in rat PVH.
Spec (investigated) Regulation (effect) of Spec (investigated) Gene_expression (concentrations) of arginine vasopressin in PVH associated with acupuncture
11) Confidence 0.44 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16459202 Disease Relevance 0.07 Pain Relevance 0.59
The effect of acupuncture on the concentrations of arginine vasopressin (AVP), oxytocin (OXT), leucine-enkephaline (L-Ek), beta-endorphin (beta-Ep) and dynorphinA(1-13) (DynA(1-13)) was investigated in rat PVH.
Spec (investigated) Regulation (effect) of Spec (investigated) Gene_expression (concentrations) of AVP in PVH associated with acupuncture
12) Confidence 0.42 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16459202 Disease Relevance 0.07 Pain Relevance 0.59
Potentially important genes have emerged that are related to the HPA axis, e.g., those that affect AVP, CRH, or cortisol synthesis as well as the production of their respective receptors.
Regulation (affect) of Gene_expression (production) of AVP
13) Confidence 0.39 Published 2010 Journal Qual Life Res Section Body Doc Link PMC2977055 Disease Relevance 0.87 Pain Relevance 0.32
By immunocytochemical methods, it was shown previously that dynorphin-like immunoreactivity is present in the posterior pituitary and the cells of the hypothalamic neurosecretory magnocellular nuclei which also are responsible for the synthesis of oxytocin, vasopressin, and their neurophysins.
Regulation (responsible) of Gene_expression (synthesis) of vasopressin in posterior pituitary associated with dynorphin
14) Confidence 0.38 Published 1982 Journal Science Section Abstract Doc Link 6121376 Disease Relevance 0 Pain Relevance 0.51
The effect of hemorrhagic shock (40% of blood vol) on the distribution of immunoreactive dynorphin A (Dyn A-IR), [Arg8]vasopressin (AVP-IR), and [Leu5]enkephalin (LE-IR) in the pituitary and brain nuclei was studied in the conscious rat.
Regulation (effect) of Gene_expression (distribution) of AVP-IR in pituitary associated with dynorphin, enkephalin and hemorrhagic shock
15) Confidence 0.34 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 2863984 Disease Relevance 0.27 Pain Relevance 0.27
The effect of hemorrhagic shock (40% of blood vol) on the distribution of immunoreactive dynorphin A (Dyn A-IR), [Arg8]vasopressin (AVP-IR), and [Leu5]enkephalin (LE-IR) in the pituitary and brain nuclei was studied in the conscious rat.
Regulation (effect) of Gene_expression (distribution) of vasopressin in pituitary associated with dynorphin, enkephalin and hemorrhagic shock
16) Confidence 0.30 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 2863984 Disease Relevance 0.27 Pain Relevance 0.27
The aim of this study was to examine the effect of i.v. methadone on the plasma arginine-vasopressin (AVP) levels and urine production in 9 conscious dogs.
Spec (examine) Regulation (effect) of Gene_expression (production) of arginine-vasopressin in urine associated with methadone
17) Confidence 0.25 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3609122 Disease Relevance 0.06 Pain Relevance 0.38
Similarly, there was a decrease in intensity of AVP mRNA expression in the parvocellular and magnocellular neurones of the PVN in the morphine-group injected with saline, suggesting a decreased synthesis of AVP in these neurones.
Regulation (intensity) of Gene_expression (expression) of AVP mRNA in PVN associated with morphine
18) Confidence 0.24 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716409 Disease Relevance 0 Pain Relevance 1.01
As a test, the method was applied to the detection of changes in AVP synthesis in diabetic rats.
Regulation (changes) of Gene_expression (synthesis) of AVP associated with diabetes mellitus
19) Confidence 0.23 Published 1991 Journal Life Sci. Section Abstract Doc Link 1677440 Disease Relevance 0.19 Pain Relevance 0.43
Together, the results indicate that the colchicine procedure is useful in detecting changes in the syntheses of some (AVP and OXT) but not all (SRIF) neuropeptides, and that when applicable, the method is sufficiently sensitive to detect changes in small hypothalamic regions.
Regulation (changes) of Gene_expression (syntheses) of AVP associated with neuropeptide and somatostatin
20) Confidence 0.23 Published 1991 Journal Life Sci. Section Abstract Doc Link 1677440 Disease Relevance 0.18 Pain Relevance 0.44

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