INT137454

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 88
Total Number 91
Disease Relevance 85.32
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADIPOQ) extracellular space (ADIPOQ) extracellular region (ADIPOQ)
endoplasmic reticulum (ADIPOQ)
Anatomy Link Frequency
plasma 8
plaque 6
adipocytes 6
adipose tissue 4
coronary artery 3
ADIPOQ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 147 100.00 Very High Very High Very High
depression 108 100.00 Very High Very High Very High
Inflammation 859 99.60 Very High Very High Very High
Angina 147 98.04 Very High Very High Very High
chemokine 11 92.28 High High
Inflammatory mediators 56 92.04 High High
Inflammatory marker 41 91.08 High High
Nerve growth factor 1 85.92 High High
Bioavailability 15 84.80 Quite High
headache 10 83.92 Quite High
Disease Link Frequency Relevance Heat
Obesity 2401 100.00 Very High Very High Very High
Insulin Resistance 845 100.00 Very High Very High Very High
Metabolic Syndrome 837 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 609 100.00 Very High Very High Very High
Depression 213 100.00 Very High Very High Very High
Heart Rate Under Development 214 99.82 Very High Very High Very High
Myocardial Infarction 429 99.64 Very High Very High Very High
INFLAMMATION 1021 99.60 Very High Very High Very High
Urological Neuroanatomy 27 99.60 Very High Very High Very High
Coronary Artery Disease 463 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured serum adiponectin levels in 303 patients with stable typical or atypical chest pain, who underwent dual-source multi-slice CT-angiography to exclude coronary artery stenosis.
Gene_expression (levels) of adiponectin in chest associated with coronary stenosis and angina
1) Confidence 0.78 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2649379 Disease Relevance 1.07 Pain Relevance 0.10
Serum SHBG
    was significantly and independently associated with serum adiponectin levels among women. 
Gene_expression (levels) of adiponectin
2) Confidence 0.70 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.93 Pain Relevance 0.11
On this basis the aim of our study was to evaluate plasma levels of adiponectin, resistin and IL-6 in subjects with diabetic foot in comparison with subjects without foot complications.


Gene_expression (levels) of adiponectin in plasma associated with diabetic foot ulcer
3) Confidence 0.68 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2946274 Disease Relevance 1.99 Pain Relevance 0.35
Serum adiponectin levels were measured in a single sample, which might limited the observed associations.
Gene_expression (levels) of adiponectin
4) Confidence 0.68 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2694800 Disease Relevance 0.83 Pain Relevance 0
In a fully adjusted multivariate model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, family history of CAD, LDL-C, HDL-C, triglycerides, hsCRP, medication and PAT volume, adiponectin levels were predictive of coronary atherosclerotic plaque burden, i.e. an increase in adiponectin levels by 27.8 µg/ml is associated with the reduction of one atherosclerotic plaque (estimate: ?
Gene_expression (levels) of adiponectin in plaque associated with heart rate under development, coronary artery disease, nicotine addiction, diabetes mellitus, atherosclerotic plaque, obesity, hypertension and disorder of lipid metabolism
5) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.54 Pain Relevance 0
However, comparing adiponectin concentrations in serum aliquots stored for 21 and 33 months at ?
Gene_expression (concentrations) of adiponectin
6) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.55 Pain Relevance 0
Adiponectin levels did not differ significantly between the two timepoints (21 months: 5.6±1.2 (mean±standard deviation) µg/ml versus 33 months: 5.3±1.1 µg/ml; p?
Gene_expression (levels) of Adiponectin
7) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.64 Pain Relevance 0
In bivariate analysis, adiponectin levels were negatively correlated with total number of coronary artery plaques (r?
Gene_expression (levels) of adiponectin in plaques
8) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.55 Pain Relevance 0
Furthermore, an increase in adiponectin levels by 13.2 µg/ml is associated with the reduction of one non-calcified plaque (estimate: ?
Gene_expression (levels) of adiponectin in plaque
9) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.50 Pain Relevance 0
To determine whether storage conditions may have affected adiponectin levels, adiponectin concentrations in aliquots stored for 21 and 33 months at ?
Gene_expression (levels) of adiponectin
10) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.67 Pain Relevance 0
Our study also showed significant association between adiponectin levels in patients with ST elevation MI and non-ST elevation MI in spite of their different pathophysiology [23,24].
Gene_expression (levels) of adiponectin associated with myocardial infarction
11) Confidence 0.67 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2694800 Disease Relevance 1.69 Pain Relevance 0.19
It
    may be hypothesized that low SHBG in obese women is independently related to generation of
    functionally defective adiponectin, which might not afford enough protection against
    inflammatory processes, obscuring the manifestation of an inverse relationship between obesity
    and adiponectin levels. 
Gene_expression (levels) of adiponectin associated with inflammation and obesity
12) Confidence 0.61 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.99 Pain Relevance 0.13
We recently reported also that sex hormone-binding globulin
   (SHBG) is an important determinant of dyslipidemia and cardiometabolic disorders, especially in
   women, independent of abdominal obesity and insulin resistance 10 which warrants the investigation also of the association between SHBG and
   adiponectin levels.
Gene_expression (levels) of adiponectin associated with metabolic syndrome and insulin resistance
13) Confidence 0.61 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.07 Pain Relevance 0.11
The latter type of anti-inflammatory
    properties manifested herein by significant independent associations between adiponectin levels
    and CRP or HDL among men. 
Gene_expression (levels) of adiponectin associated with inflammation and disorder of lipid metabolism
14) Confidence 0.61 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.36 Pain Relevance 0.22
In a linear regression analysis for WC (or BMI) in a subset of
    the sample in which serum sex hormone-binding globulin (SHBG) was available and which
    additionally comprised adiponectin, fasting insulin and other confounders, only insulin and, in
    women SHBG, were significantly associated, but not adiponectin. 
Gene_expression (comprised) of adiponectin
15) Confidence 0.61 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2491727 Disease Relevance 0.29 Pain Relevance 0.04
It has been pointed out that SNPs for adiponectin receptor-1
    gene were significant in obese but not in combined lean and obese subjects, suggesting
    gene-environment interactions, such that polymorphisms may influence obesity-associated
    comorbidities only when individual is obese 25.
Gene_expression (pointed) of adiponectin associated with obesity
16) Confidence 0.61 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.48 Pain Relevance 0.18
Adiponectin is the most abundant adipokine produced by adipose tissue.
Gene_expression (produced) of Adiponectin in adipose tissue associated with obesity
17) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 2.09 Pain Relevance 0.12
Serum levels of adiponectin are markedly decreased in patients with visceral obesity and states of insulin resistance such as non-alcoholic fatty liver disease and type 2 diabetes [7], [8].
Gene_expression (levels) of adiponectin in liver associated with diabetes mellitus, obesity, disease, alcoholic fatty liver and insulin resistance
18) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 2.09 Pain Relevance 0.12
Our data suggest that the number of mixed and non-calcified plaques decrease by 1 for each 11.5 µg/ml and 13.2 µg/ml increase in serum adiponectin levels, respectively.
Gene_expression (levels) of adiponectin in plaques
19) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.53 Pain Relevance 0.08
Adiponectin levels in the AIV were lower than levels in the Ao.
Gene_expression (levels) of Adiponectin in AIV
20) Confidence 0.60 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16877558 Disease Relevance 0.16 Pain Relevance 0.11

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