INT13748

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Context Info
Confidence 0.41
First Reported 1988
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.63
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
hypothalamus 2
median eminence 2
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 16 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
antagonist 4 99.16 Very High Very High Very High
narcan 4 91.80 High High
Dynorphin 3 90.00 High High
agonist 7 87.84 High High
opiate 2 86.72 High High
Opioid 4 83.12 Quite High
opioid receptor 2 75.00 Quite High
Delta opioid receptors 1 61.00 Quite High
Disease Link Frequency Relevance Heat
Frailty 4 95.92 Very High Very High Very High
Hyperglycemia 1 93.28 High High
Aids-related Complex 5 82.80 Quite High
Sprains And Strains 2 67.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to examine prolactin (PRL) regulation of preproenkephalin and proopiomelanocortin (POMC) gene expression in the hypothalamus during lactation.
Spec (examine) Negative_regulation (examine) of Spec (examine) Regulation (regulation) of proopiomelanocortin in hypothalamus
1) Confidence 0.41 Published 2003 Journal Endocrine Section Abstract Doc Link 12668876 Disease Relevance 0.15 Pain Relevance 0
Experiment 4 found that blockade of the mu-receptor by intraventricular pretreatment with the specific antagonist beta-funaltrexamine (20 micrograms/rat, 24 h before) completely abolished the effects of DAGO and beta-endorphin on glucose and corticosterone.
Negative_regulation (abolished) of Regulation (effects) of beta-endorphin associated with antagonist
2) Confidence 0.41 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1677542 Disease Relevance 0.09 Pain Relevance 0.83
Maternal adrenalectomy also prevented the effects of prenatal morphine on hypothalamic content of CRF, CRF immunofluorescence in the median eminence, and POMC mRNA in the anterior pituitary gland.
Negative_regulation (prevented) of Regulation (effects) of POMC mRNA in median eminence associated with morphine
3) Confidence 0.41 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663647 Disease Relevance 0.26 Pain Relevance 0.90
Responses to both [D-Ala2,MePhe4,Gly(ol)5]enkephalin and beta-endorphin were attenuated by the irreversible antagonists beta-funaltrexamine and beta-chlornaltrexamine.
Negative_regulation (attenuated) of Regulation (Responses) of beta-endorphin associated with antagonist and enkephalin
4) Confidence 0.17 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2853057 Disease Relevance 0.13 Pain Relevance 0.77

General Comments

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