INT137503

Context Info Confidence 0.67 First Reported 2006 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 6 Total Number 7 Disease Relevance 4.66 Pain Relevance 0.74

cytosol (Casp9) peptidase activity (Casp9) mitochondrion (Casp9) nucleus (Casp9) cytoplasm (Casp9)

Anatomy Link Frequency primary neurons 2 Casp9 (Mus musculus)

Pain Link Frequency Relevance Heat aspirin 8 99.78 cINOD 5 82.08 COX-2 inhibitor 20 80.16 ischemia 7 68.32 alcohol 14 50.00 Substantia nigra 8 5.00 anesthesia 7 5.00 isoflurane 3 5.00 imagery 3 5.00 ketamine 2 5.00

Disease Link Frequency Relevance Heat Injury 13 98.84 Death 100 98.52 Apoptosis 144 97.76 Retinoblastoma 2 89.88 Drug Induced Neurotoxicity 10 87.88 Targeted Disruption 8 87.72 Cancer 101 82.92 INFLAMMATION 4 81.52 Congenital Anomalies 1 75.68 Hepatotoxicity 2 75.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results showed that administration of indomethacin to PiZ mice resulted in increased hepatic injury, indicated by increased hepatocellular proliferation and increased activation of caspase 9.

Positive_regulation (increased) of Positive_regulation (activation) of caspase 9 associated with injury

1) Confidence 0.67 Published 2006 Journal Hepatology Section Abstract Doc Link 17006946 Disease Relevance 1.13 Pain Relevance 0.23

Finally, we have shown that aspirin treatment caused changes in the mitochondrial membrane potential, release of cytochrome c from mitochondria, and activation of caspase-9 and -3, which could be because of the proteasomal dysfunction.

Positive_regulation (caused) of Positive_regulation (activation) of caspase-9 associated with aspirin

2) Confidence 0.33 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16880202 Disease Relevance 0.55 Pain Relevance 0.34

Significantly elevated activities of caspase-3, caspase-8 and caspase-9 were observed in BJMC3879luc2 cells treated with raloxifene for 24 h (Figure 2B) and 48 h (data not shown), as compared to the respective controls.

Positive_regulation (elevated) of Positive_regulation (activities) of caspase-9

3) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.45 Pain Relevance 0

To further characterize the intracellular pathways involved in the cell death induced by MPP+, we examined by fluorimetric assays and Western blot the activation of caspase-9 and caspase-3 after incubation with MPP+ in the presence or in the absence of pre-treatment with LiCl and kenpaullone (Figure 3).

Spec (examined) Positive_regulation (after) of Spec (examined) Positive_regulation (activation) of caspase-9 associated with death

4) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.25 Pain Relevance 0

The MPP+ treatment induced a significant activation of caspase-9 in both neuronal models as compared to the untreated control, the maximal significant effect being observed after a 2 h-treatment for TSM1 cells and a 1 h-treatment for primary neurons (129.37±11.61% and 165.80±10.92% compared to the control conditions taken as 100%, Figure 3A and 3D).

Positive_regulation (induced) of Positive_regulation (activation) of caspase-9 in primary neurons

5) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.23 Pain Relevance 0

The fact that the ADH transgene augmented the ethanol-induced cytosolic accumulation of pro-caspase-9 and cytochrome C further substantiated the critical role of acetaldehyde in ethanol-induced mitochondrial damage, which is consistent with the ADH-accentuated mitochondrial O2•?

Positive_regulation (induced) of Positive_regulation (accumulation) of pro-caspase-9

6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.45 Pain Relevance 0.06

These findings are consistent with others showing that celecoxib enhances caspase-3 or caspase-9 activation through PGE2 inhibition [42,43].

Positive_regulation (enhances) of Positive_regulation (activation) of caspase-9

7) Confidence 0.03 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.59 Pain Relevance 0.11

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