INT137503
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Our results showed that administration of indomethacin to PiZ mice resulted in increased hepatic injury, indicated by increased hepatocellular proliferation and increased activation of caspase 9. | |||||||||||||||
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Finally, we have shown that aspirin treatment caused changes in the mitochondrial membrane potential, release of cytochrome c from mitochondria, and activation of caspase-9 and -3, which could be because of the proteasomal dysfunction. | |||||||||||||||
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Significantly elevated activities of caspase-3, caspase-8 and caspase-9 were observed in BJMC3879luc2 cells treated with raloxifene for 24 h (Figure 2B) and 48 h (data not shown), as compared to the respective controls. | |||||||||||||||
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To further characterize the intracellular pathways involved in the cell death induced by MPP+, we examined by fluorimetric assays and Western blot the activation of caspase-9 and caspase-3 after incubation with MPP+ in the presence or in the absence of pre-treatment with LiCl and kenpaullone (Figure 3). | |||||||||||||||
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The MPP+ treatment induced a significant activation of caspase-9 in both neuronal models as compared to the untreated control, the maximal significant effect being observed after a 2 h-treatment for TSM1 cells and a 1 h-treatment for primary neurons (129.37±11.61% and 165.80±10.92% compared to the control conditions taken as 100%, Figure 3A and 3D). | |||||||||||||||
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The fact that the ADH transgene augmented the ethanol-induced cytosolic accumulation of pro-caspase-9 and cytochrome C further substantiated the critical role of acetaldehyde in ethanol-induced mitochondrial damage, which is consistent with the ADH-accentuated mitochondrial O2? | |||||||||||||||
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These findings are consistent with others showing that celecoxib enhances caspase-3 or caspase-9 activation through PGE2 inhibition [42,43]. | |||||||||||||||
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