INT137504

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.71
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 8 99.76 Very High Very High Very High
antagonist 8 91.84 High High
cINOD 9 72.64 Quite High
agonist 22 58.80 Quite High
dexamethasone 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 3 99.04 Very High Very High Very High
Cancer 182 95.20 Very High Very High Very High
Congenital Anomalies 1 90.48 High High
Breast Cancer 110 88.28 High High
Apoptosis 17 83.52 Quite High
Pancreatic Cancer 2 74.16 Quite High
INFLAMMATION 11 72.40 Quite High
Hyperplasia 2 47.32 Quite Low
Toxicity 10 5.00 Very Low Very Low Very Low
Colon Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aspirin exposure also resulted in an increase in the half-life of pd1EGFP, a model substrate of proteasome, as well as various intracellular substrates like Bax, IkappaB-alpha, p53, and p27(kip1).
Positive_regulation (resulted) of Positive_regulation (increase) of kip1 associated with aspirin
1) Confidence 0.45 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16880202 Disease Relevance 0.65 Pain Relevance 0.38
in mediating CDIM9 induction of caveolin-1 and p27, MDA-MB231 cells were treated with 10 or 20 ?
Positive_regulation (mediating) of Positive_regulation (induction) of p27
2) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.21 Pain Relevance 0.05
The induction of p27, but not that of caveolin-1, was dependent on the concentration of CDIM9 in vitro.
Positive_regulation (dependent) of Positive_regulation (induction) of p27
3) Confidence 0.15 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.85 Pain Relevance 0.03

General Comments

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