INT137505

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 10.55
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Anatomy Link Frequency
amacrine cells 1
brain 1
cleavage 1
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 16 99.76 Very High Very High Very High
qutenza 7 99.12 Very High Very High Very High
antagonist 36 98.16 Very High Very High Very High
agonist 93 87.36 High High
cINOD 38 72.04 Quite High
gABA 4 49.44 Quite Low
Neurotransmitter 4 48.64 Quite Low
fibrosis 18 22.56 Low Low
dexamethasone 16 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 990 98.64 Very High Very High Very High
Death 25 98.44 Very High Very High Very High
Breast Cancer 447 97.68 Very High Very High Very High
Glioma 104 94.60 High High
Apoptosis 216 93.84 High High
Hepatocellular Cancer 78 92.56 High High
Congenital Anomalies 2 89.88 High High
Pancreatic Cancer 8 89.28 High High
Stomach Cancer 109 87.52 High High
Hyperplasia 16 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aspirin exposure also resulted in an increase in the half-life of pd1EGFP, a model substrate of proteasome, as well as various intracellular substrates like Bax, IkappaB-alpha, p53, and p27(kip1).
Positive_regulation (increase) of kip1 associated with aspirin
1) Confidence 0.67 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16880202 Disease Relevance 0.64 Pain Relevance 0.38
Aspirin exposure also resulted in an increase in the half-life of pd1EGFP, a model substrate of proteasome, as well as various intracellular substrates like Bax, IkappaB-alpha, p53, and p27(kip1).
Positive_regulation (increase) of p27 associated with aspirin
2) Confidence 0.39 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16880202 Disease Relevance 0.64 Pain Relevance 0.37
Thus, increased activity of the p27 promoter expressed as luciferase expression with the promoter constructs indicate that the regulation of p27Kip1 protein levels by cathepsin B and uPAR could be, at least partially, explained by the regulation of its promoter activity by increased expression of FOXO3a.
Positive_regulation (increased) of p27
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.06 Pain Relevance 0
in mediating CDIM9 induction of caveolin-1 and p27, MDA-MB231 cells were treated with 10 or 20 ?
Positive_regulation (induction) of p27
4) Confidence 0.23 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.21 Pain Relevance 0.05
activation and upregulation of the cell cycle regulating genes p27 and caveolin-1.
Positive_regulation (upregulation) of p27
5) Confidence 0.23 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.80 Pain Relevance 0
The induction of p27, but not that of caveolin-1, was dependent on the concentration of CDIM9 in vitro.
Positive_regulation (induction) of p27
6) Confidence 0.23 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.84 Pain Relevance 0.03
Since we observed p27Kip1 upregulation with decreased cell proliferation and G0/G1 phase arrest with the depletion of cathepsin B and uPAR, we next determined the expression of FOXO proteins, which are important transcriptional regulators of the p27Kip1 promoter.
Positive_regulation (upregulation) of p27Kip1
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
However, pCU-treated brain sections showed very little or no expression of Ki67 as compared to the controls (Fig. 6B), indicating that cell proliferation is inhibited by these treatments through upregulation of p27Kip1.
Positive_regulation (upregulation) of p27Kip1 in brain
8) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.74 Pain Relevance 0
In the present study, we show that the co-depletion of cathepsin B and uPAR arrests cells in the G1 phase primarily through the upregulation of p27Kip1 and that this pathway involves the downregulation of p-PI3K, p-AKT, D-type cyclin expression, and cyclin E/Cdk2 complex formation as well as the subsequent upregulation of the FOXO3a protein and its nuclear localization.
Positive_regulation (upregulation) of p27Kip1
9) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.63 Pain Relevance 0
In order to explore the underlying molecular mechanism of CIAPIN1 affecting the cell cycle progression, we detected the expression of cell cycle-related molecules in AdSiCIAPIN1-infected SMMC-7721 cells, such as cyclinD1, p27, cdk2, cdk4 and p21 by western blot and found cdk2, cdk4 and p21 were not affected (data not show), except CyclyinD1 was downregulated and P27 was upregulated (Figure3F).
Positive_regulation (upregulated) of P27
10) Confidence 0.17 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.08 Pain Relevance 0
Co-treatment of GW9662 inhibited the induction of caveolin-1 and p27 by CDIM9 in MDA-MB231 cells (Figure 2a), suggesting that these responses were PPAR-?
Positive_regulation (induction) of p27
11) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.35 Pain Relevance 0.10
Neither p27 nor caveolin-1 was induced in BT549 cells after treatment with CDIM9 (Figure 2b).
Neg (Neither) Positive_regulation (induced) of p27
12) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.25 Pain Relevance 0.04
The greater induction of caveolin-1 compared with p27 in vivo may reflect pharmacologic barriers preventing the drug from reaching all of the tumor cells in vivo.
Positive_regulation (induction) of p27 associated with cancer
13) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.91 Pain Relevance 0.03
CDIM9 increased p27 expression level in MDA-MB231 cells in a concentration-dependent manner.
Positive_regulation (increased) of p27
14) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.24 Pain Relevance 0
In our study, induction of p27 by CDIM9 was PPAR-?
Positive_regulation (induction) of p27
15) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.83 Pain Relevance 0.09
In contrast, cell-cycle regulator p27(KIP1), caspase activity as well as poly-ADP ribose polymerase (PARP) cleavage were increased.
Positive_regulation (increased) of p27 in cleavage
16) Confidence 0.13 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.90 Pain Relevance 0.45
In addition, VPA induced alterations in the expression of other cell cycle-related proteins, such as p27 and cyclin D1.
Positive_regulation (induced) of p27
17) Confidence 0.09 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.59 Pain Relevance 0
The level of p27 showed a gradual increase for up to 48 h.
Positive_regulation (increase) of p27
18) Confidence 0.09 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.24 Pain Relevance 0
-tubulin, and p21WAF1 levels accompanied by upregulation of p27, caspase 3, and caspase 9, and downregulation of bcl-2, cyclin D1, and survivin.
Positive_regulation (upregulation) of p27
19) Confidence 0.04 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2994814 Disease Relevance 0.60 Pain Relevance 0
However, the relative levels of immunolabeling for these proteins within the cholinergic cells are either decreased (Pax6) or increased (CRABP and p27kip1) compared to levels seen in other types of differentiating amacrine cells.
Positive_regulation (increased) of p27kip1 in amacrine cells
20) Confidence 0.03 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox