INT137510

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) mitochondrion (Nfkb1) DNA binding (Nfkb1)
protein complex (Nfkb1) transmembrane transport (ABCB1) cytoplasm (Nfkb1)
Nfkb1 (Mus musculus)
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 75.28 Quite High
cINOD 1 70.56 Quite High
aspirin 2 67.60 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 2 99.96 Very High Very High Very High
Cancer 8 90.76 High High
INFLAMMATION 1 69.12 Quite High
Toxicity 1 38.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytotoxic treatment selects for such up-regulation inasmuch as NF-kappaB promotes transcription of a large number of proteins that inhibit both the intrinsic and extrinsic pathways of apoptosis; NF-kappaB also boosts expression of mdr1, which expels many drugs from cells.
NF-kappaB Positive_regulation (boosts) of Gene_expression (expression) of mdr1 associated with apoptosis
1) Confidence 0.17 Published 2006 Journal Integr Cancer Ther Section Abstract Doc Link 16880431 Disease Relevance 0.59 Pain Relevance 0.14

General Comments

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