INT137512

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.91
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
Anatomy Link Frequency
apoptotic cell 2
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 12 99.98 Very High Very High Very High
dexamethasone 63 99.36 Very High Very High Very High
Pain 6 67.80 Quite High
COX-2 inhibitor 52 67.60 Quite High
cINOD 20 63.48 Quite High
Inflammation 27 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 290 100.00 Very High Very High Very High
Death 46 100.00 Very High Very High Very High
Prostate Cancer 14 100.00 Very High Very High Very High
Injury 7 99.48 Very High Very High Very High
Toxicity 6 96.80 Very High Very High Very High
Stress 26 79.44 Quite High
Cancer 139 78.28 Quite High
Skin Cancer 6 76.72 Quite High
Immunotherapy Of Cancer 2 76.20 Quite High
INFLAMMATION 32 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown that RNA levels of proapoptotic bax were consistently decreased after marathon, whereas, RNA levels of antiapoptotic bcl-2 were slightly increased after marathon thereby causing a decreased bax: bcl-2 ratio (Figure 2B, C).
Positive_regulation (increased) of Positive_regulation (causing) of bax
1) Confidence 0.49 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.59 Pain Relevance 0
We have shown that RNA levels of proapoptotic bax were consistently decreased after marathon, whereas, RNA levels of antiapoptotic bcl-2 were slightly increased after marathon thereby causing a decreased bax: bcl-2 ratio (Figure 2B, C).
Positive_regulation (causing) of Positive_regulation (decreased) of bax
2) Confidence 0.49 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.58 Pain Relevance 0
Diclofenac induced early (9 h) activation of Bax and Bak and caused mitochondrial translocation of Bax, indicating that MOMP was involved in cell death.
Positive_regulation (induced) of Positive_regulation (activation) of Bax associated with diclofenac and death
3) Confidence 0.44 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18191430 Disease Relevance 0.88 Pain Relevance 0.46
Here, we have shown that amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax.
Positive_regulation (induces) of Positive_regulation (up-regulation) of Bax in apoptotic cell associated with prostate cancer, apoptosis and death
4) Confidence 0.40 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880611 Disease Relevance 1.62 Pain Relevance 0.07
TMZ induced apoptosis with an increase in Bax:Bcl-2 ratio
Positive_regulation (induced) of Positive_regulation (increase) of Bax associated with apoptosis
5) Confidence 0.35 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.62 Pain Relevance 0.23
Bromelain treatment induces up-regulation of p53 and Bax and subsequent activation of caspase-3 and caspase-9 with a decrease in Bcl-2 expression [154].
Positive_regulation (induces) of Positive_regulation (up-regulation) of Bax
6) Confidence 0.16 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.63 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox