INT137513

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.30
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
brain 2
apoptotic cell 2
reticulum 2
A172 2
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 11 98.94 Very High Very High Very High
Kinase C 3 98.56 Very High Very High Very High
opiate 7 97.88 Very High Very High Very High
dexamethasone 63 94.68 High High
tolerance 2 83.28 Quite High
Inflammation 6 77.12 Quite High
ischemia 22 72.00 Quite High
Pain 6 63.48 Quite High
corticosteroid 1 49.92 Quite Low
methadone 1 45.60 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 281 100.00 Very High Very High Very High
Prostate Cancer 6 99.22 Very High Very High Very High
Death 37 98.40 Very High Very High Very High
Glioblastoma 49 95.12 Very High Very High Very High
Leukemia 1 81.92 Quite High
INFLAMMATION 7 77.12 Quite High
Glioma 1 75.00 Quite High
Cv Unclassified Under Development 21 72.00 Quite High
Immunotherapy Of Cancer 1 71.88 Quite High
Cancer 24 68.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of A172 cells with capsaicin inhibited cell growth and induced apoptosis through down-regulation of Bcl-2 and activation of caspase-3.
Negative_regulation (down-regulation) of Positive_regulation (activation) of Bcl-2 in A172 associated with qutenza and apoptosis
1) Confidence 0.35 Published 2008 Journal Life Sci. Section Abstract Doc Link 18405923 Disease Relevance 0.45 Pain Relevance 0.72
Here, we have shown that amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax.
Negative_regulation (down-regulation) of Positive_regulation (up-regulation) of Bcl-2 in apoptotic cell associated with prostate cancer, apoptosis and death
2) Confidence 0.32 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880611 Disease Relevance 1.56 Pain Relevance 0.06
Preconditioning causes a decrease in pro-apoptotic Bax and increase in the anti-apoptotic Bcl-2 proteins resulting in an altered Bcl-2/Bax ratio and attenuation of cytochrome c release from mitochondria (Maulik et al 1999, 2000; Nakamura et al 2000).
Negative_regulation (decrease) of Positive_regulation (increase) of Bcl-2 associated with apoptosis
3) Confidence 0.28 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 1.29 Pain Relevance 0.15
Instead, the chronic modulation of some of their components (downregulation of FADD and cytochrome c; upregulation of FLIP(L) and Bcl-2) suggests the induction of non-apoptotic actions by opiate drugs related to phenomena of synaptic plasticity in the brain.
Negative_regulation (downregulation) of Positive_regulation (upregulation) of Bcl-2 in brain associated with opiate and apoptosis
4) Confidence 0.26 Published 2008 Journal Neuroscience Section Abstract Doc Link 18834930 Disease Relevance 0.76 Pain Relevance 0.49
Upregulation of Bcl-2 either directly or indirectly can repress the Ca2+ flux across the membrane of endoplasmic reticulum, thereby abrogating apoptosis via Ca2+ signaling [39].
Negative_regulation (repress) of Positive_regulation (Upregulation) of Bcl-2 in reticulum associated with apoptosis
5) Confidence 0.25 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.90 Pain Relevance 0.20
However, STS is a strong apoptosis inducer, and the induction of BCL2 in infected cells may be sufficient to prevent cytochrome c release in the absence of STS.
Negative_regulation (prevent) of Positive_regulation (induction) of BCL2 associated with apoptosis
6) Confidence 0.14 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.35 Pain Relevance 0

General Comments

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