INT13752

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Context Info
Confidence 0.36
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 5.68
Pain Relevance 14.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn4a)
Anatomy Link Frequency
tail 1
brain 1
skeletal muscle 1
oocytes 1
muscle cell 1
Scn4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 21 100.00 Very High Very High Very High
opiate 12 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Opioid 42 99.98 Very High Very High Very High
Substantia nigra 6 99.84 Very High Very High Very High
Morphine 10 99.72 Very High Very High Very High
Enkephalin 46 99.66 Very High Very High Very High
Analgesic 14 99.28 Very High Very High Very High
agonist 18 99.04 Very High Very High Very High
sodium channel 14 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Paralysis 44 99.70 Very High Very High Very High
Urological Neuroanatomy 16 99.68 Very High Very High Very High
Myotonic Disorders 1 98.96 Very High Very High Very High
Congenital Anomalies 10 98.44 Very High Very High Very High
Hyperkalemic Periodic Paralysis 1 98.42 Very High Very High Very High
Pruritus 12 97.52 Very High Very High Very High
Disease 19 96.24 Very High Very High Very High
Syndrome 6 95.60 Very High Very High Very High
Respiratory Failure 4 95.08 Very High Very High Very High
Starvation 8 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The close association between microsomal CYP4 ?
micro Binding (association) of
1) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.20 Pain Relevance 0.09
In oocytes, beta 1 interacts functionally with SkM1 to modulate the abnormally slow inactivation kinetics observed with this alpha subunit expressed alone.
SkM1 Binding (interacts) of in oocytes
2) Confidence 0.34 Published 1993 Journal Neuron Section Abstract Doc Link 8240813 Disease Relevance 0 Pain Relevance 0.19
We conclude that a common beta 1 subunit is expressed in skeletal muscle, heart, and brain and that in skeletal muscle, this subunit is specifically associated with the SkM1, rather than the SkM2, sodium channel isoform.
SkM1 Binding (associated) of in brain associated with sodium channel
3) Confidence 0.29 Published 1993 Journal Neuron Section Abstract Doc Link 8240813 Disease Relevance 0 Pain Relevance 0.20
Using a computerized autoradiographic subtraction technique, we have examined the regional distribution of meptazinol-sensitive [3H][D-Ala2,MePhe4,Gly(ol)5]enkephalin (DAGO) binding and compared this with the distribution of mu 1 binding determined by competition with low [D-Ala2,D-Leu5]enkephalin (DADL) concentrations. 2.
mu 1 Binding (binding) of associated with enkephalin
4) Confidence 0.25 Published 1988 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 2852061 Disease Relevance 0.15 Pain Relevance 1.17
DAGO is a selective ligand for the mu 1 site, whilst DADLE interacts with mu 1 and delta sites with similar affinities.
mu 1 Binding (interacts) of
5) Confidence 0.23 Published 1986 Journal J. Recept. Res. Section Abstract Doc Link 3012081 Disease Relevance 0 Pain Relevance 0.50
DAGO is a selective ligand for the mu 1 site, whilst DADLE interacts with mu 1 and delta sites with similar affinities.
mu 1 Binding (ligand) of
6) Confidence 0.17 Published 1986 Journal J. Recept. Res. Section Abstract Doc Link 3012081 Disease Relevance 0 Pain Relevance 0.51
Binding of 3H-naloxone to the mu 1 and mu 2 sites was differentially inhibited by opioids.
mu 1 Binding (Binding) of associated with narcan and opioid
7) Confidence 0.17 Published 1986 Journal J. Recept. Res. Section Abstract Doc Link 3012081 Disease Relevance 0 Pain Relevance 0.43
The correlation between the inhibition of [3H]DAGO binding by meptazinol and that by DADL was high (r = 0.83), consistent with the binding of meptazinol to mu 1 sites.
mu 1 Binding (binding) of associated with enkephalin
8) Confidence 0.16 Published 1988 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 2852061 Disease Relevance 0.18 Pain Relevance 1.08
Compared to mu 2 binding, DADLE and DAGO preferentially inhibited mu 1 binding.
mu 1 Binding (binding) of
9) Confidence 0.15 Published 1986 Journal J. Recept. Res. Section Abstract Doc Link 3012081 Disease Relevance 0 Pain Relevance 0.46
Hyperkalemic Periodic Paralysis and Paramyotonia Congenita are rare forms of Periodic Paralysis that are also associated SCN4A mutations that cause gain-of-function abnormalities in the sodium channel resulting in prolonged muscle cell excitation [12].
SCN4A Binding (associated) of in muscle cell associated with congenital anomalies, sodium channel, myotonic disorders, paralysis and hyperkalemic periodic paralysis
10) Confidence 0.15 Published 2008 Journal Cases J Section Body Doc Link PMC2584072 Disease Relevance 1.51 Pain Relevance 0.08
It is concluded that 3H-opioids bind to at least three sites--mu 1, mu 2 and delta.
mu 1 Binding (bind) of associated with opioid
11) Confidence 0.15 Published 1986 Journal J. Recept. Res. Section Abstract Doc Link 3012081 Disease Relevance 0 Pain Relevance 0.52
Mu1 binding was slightly more sensitive to the lesioning than mu2 binding.
Mu1 Binding (binding) of
12) Confidence 0.14 Published 1988 Journal Life Sci. Section Abstract Doc Link 2848168 Disease Relevance 0 Pain Relevance 0.43
Loss of striatal mu1 opiate binding by substantia nigra lesions in the rat.
mu1 Binding (binding) of in substantia nigra associated with substantia nigra, enkephalin and opiate
13) Confidence 0.13 Published 1988 Journal Life Sci. Section Title Doc Link 2848168 Disease Relevance 0 Pain Relevance 0.56
Mu1 binding was slightly more sensitive to the lesioning than mu2 binding.
Mu1 Binding (binding) of
14) Confidence 0.11 Published 1988 Journal Life Sci. Section Abstract Doc Link 2848168 Disease Relevance 0 Pain Relevance 0.43
Over the past decade mutations in genes encoding three ion channels, CACN1AS, SCN4A and KCNJ2, have been identified and account for at least 70% of the identified cases of PP and several allelic disorders.
SCN4A Binding (account) of
15) Confidence 0.11 Published 2006 Journal Brain Section Abstract Doc Link 16195244 Disease Relevance 0.59 Pain Relevance 0
We conclude that a common beta 1 subunit is expressed in skeletal muscle, heart, and brain and that in skeletal muscle, this subunit is specifically associated with the SkM1, rather than the SkM2, sodium channel isoform.
SkM1 Binding (associated) of in skeletal muscle associated with sodium channel
16) Confidence 0.10 Published 1993 Journal Neuron Section Abstract Doc Link 8240813 Disease Relevance 0 Pain Relevance 0.20
We conclude that a common beta 1 subunit is expressed in skeletal muscle, heart, and brain and that in skeletal muscle, this subunit is specifically associated with the SkM1, rather than the SkM2, sodium channel isoform.
SkM1 Binding (associated) of in heart associated with sodium channel
17) Confidence 0.10 Published 1993 Journal Neuron Section Abstract Doc Link 8240813 Disease Relevance 0 Pain Relevance 0.20
Gender differences were not observed for mu1, mu2, or delta binding in hypothalamus or cortex.
mu1 Binding (binding) of in cortex
18) Confidence 0.04 Published 1991 Journal Pain Section Abstract Doc Link 1677751 Disease Relevance 0 Pain Relevance 1.19
Oxycodone shares similar pharmacodynamic properties to morphine and displays binding to the mu-1 and kappa receptors, hence its use may result in cholestatic pruritus via increased central opioidergic tone [8].
mu-1 Binding (binding) of associated with oxycodone, pruritus and morphine
19) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2396652 Disease Relevance 1.19 Pain Relevance 1.51
Since mu and delta opioid receptor subtypes have been implicated in supraspinal analgesia, the present study evaluated whether gender or adult gonadectomy altered (a) analgesia on the tail-flick and jump tests following central administration of the mu-selective agonist, [D-Ala2, Me-Phe4, Gly(ol)5] enkephalin (DAMGO) and the delta-selective agonist, [D-Ser2,Leu5] enkephalin-Thr6 (DSLET) and (b) mu1, mu2 and delta opioid receptor binding.
mu1 Binding (binding) of in tail associated with agonist, tail-flick, enkephalin, opioid receptor and analgesia
20) Confidence 0.03 Published 1991 Journal Pain Section Abstract Doc Link 1677751 Disease Relevance 0 Pain Relevance 1.32

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