INT137529

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.73
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MICA) plasma membrane (MICA) cytoplasm (MICA)
Anatomy Link Frequency
epithelial cells 2
MICA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 11 91.12 High High
corticosteroid 6 87.88 High High
cytokine 30 64.28 Quite High
spinal inflammation 2 50.00 Quite Low
Multiple sclerosis 158 5.00 Very Low Very Low Very Low
Inflammation 43 5.00 Very Low Very Low Very Low
Central nervous system 27 5.00 Very Low Very Low Very Low
cINOD 7 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 21 100.00 Very High Very High Very High
Nicotine Addiction 273 98.88 Very High Very High Very High
Pulmonary Disease 261 98.48 Very High Very High Very High
Cancer 11 94.16 High High
Cytomegalovirus Infection 1 93.36 High High
Sarcoma 1 89.44 High High
Viral Infection 5 86.04 High High
Low Back Pain 2 85.96 High High
Lung Cancer 6 82.32 Quite High
Disease 74 37.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The frequency of MICA*007 was significantly increased in AS patients, when compared with normal controls (chi-square=10.18, P<0.05, RR=2.50).
Positive_regulation (increased) of MICA
1) Confidence 0.30 Published 2006 Journal Zhonghua Yi Xue Yi Chuan Xue Za Zhi Section Body Doc Link 16883538 Disease Relevance 0.09 Pain Relevance 0
We did not detect an upregulation of MICA in bronchial biopsies from smokers or COPD subjects, and MICB was undetectable in all samples.
Positive_regulation (upregulation) of MICA associated with pulmonary disease and nicotine addiction
2) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.29 Pain Relevance 0.09
We hypothesize that the bronchial epithelium is not activated in terms of MICA or MICB, in our subjects with stable COPD.
Positive_regulation (activated) of MICA in epithelium associated with pulmonary disease
3) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.07 Pain Relevance 0
The NKG2 D ligands, MICA and B, are stress-inducible and primarily expressed on epithelial cells [32].
Positive_regulation (inducible) of MICA in epithelial cells associated with stress
4) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 0.69 Pain Relevance 0
-UTR sequences and maintains expression of MICA and MICB protein under a certain threshold and facilitates acute upregulation of MICA and MICB during cellular stres [142].
Positive_regulation (upregulation) of MICA
5) Confidence 0.08 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.60 Pain Relevance 0.03

General Comments

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